基于近红外有机染料的纳米制剂用于癌症的光热治疗。
Near-Infrared Organic Dye-Based Nanoagent for the Photothermal Therapy of Cancer.
机构信息
Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University , Beijing 100084, China.
Key Laboratory of Photochemical Conversion and Optoelectronic Materials and City U-CAS Joint Laboratory of Functional Materials and Devices, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Beijing 100190, China.
出版信息
ACS Appl Mater Interfaces. 2016 Nov 9;8(44):29899-29905. doi: 10.1021/acsami.6b07838. Epub 2016 Oct 26.
Given their easy structural modification and good biocompatibility advantages, near-infrared (NIR) organic dyes with a large molar extinction coefficient, while a superlow fluorescence quantum yield shows considerable potential application in photothermal therapy (PTT). Herein, a new NIR-absorbing asymmetric cyanine dye, namely, RC, is designed and synthesized via the hybrid of rhodamine and hemicyanine derivatives. RC-BSA nanoparticles (NPs) are fabricated by using the bovine serum albumin (BSA) matrix. The NPs exhibit a strong NIR absorption peak at ∼868 nm and 28.7% photothermal conversion efficiency. Based on these features, RC-BSA NPs exhibit excellent performance in ablating tumor under a 915 nm laser radiation through a PTT mechanism. These NPs show no obvious toxicity to the treated mice. Thus, RC-BSA NPs can used as a new NIR laser-triggered PTT agent in cancer treatment.
鉴于其易于结构修饰和良好的生物相容性优势，摩尔消光系数大、荧光量子产率极低的近红外（NIR）有机染料在光热治疗（PTT）中具有相当大的潜在应用价值。本文通过将罗丹明和半花菁衍生物混合，设计并合成了一种新型的 NIR 吸收不对称菁染料 RC。采用牛血清白蛋白（BSA）基质制备了 RC-BSA 纳米颗粒（NPs）。该 NPs 在 ∼868nm 处表现出很强的近红外吸收峰，光热转换效率为 28.7%。基于这些特性，RC-BSA NPs 通过 PTT 机制在 915nm 激光辐射下能有效地消融肿瘤。这些 NPs 对处理过的小鼠没有明显的毒性。因此，RC-BSA NPs 可用作一种新的 NIR 激光触发 PTT 剂，用于癌症治疗。
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