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NOTCH and the 2 SASPs of senescence.

作者信息

Hoare Matthew, Narita Masashi

机构信息

a University of Cambridge, Cancer Research UK Cambridge Institute, Robinson Way , Cambridge , UK.

b University of Cambridge , Department of Medicine, Addenbrooke's Hospital , Cambridge , UK.

出版信息

Cell Cycle. 2017 Feb;16(3):239-240. doi: 10.1080/15384101.2016.1248730. Epub 2016 Oct 20.

Abstract
摘要

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本文引用的文献

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NOTCH1 mediates a switch between two distinct secretomes during senescence.
Nat Cell Biol. 2016 Sep;18(9):979-92. doi: 10.1038/ncb3397. Epub 2016 Aug 15.
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An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA.
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Cellular senescence checkpoint function determines differential Notch1-dependent oncogenic and tumor-suppressor activities.
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Notch activation induces endothelial cell senescence and pro-inflammatory response: implication of Notch signaling in atherosclerosis.
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The senescence-associated secretory phenotype: the dark side of tumor suppression.
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Senescence of activated stellate cells limits liver fibrosis.
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