肺移植后移植物排斥反应的机制。
Mechanisms of graft rejection after lung transplantation.
作者信息
Hsiao Hsi-Min, Scozzi Davide, Gauthier Jason M, Kreisel Daniel
机构信息
aDepartment of Surgery bDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, Missouri, USA cDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.
出版信息
Curr Opin Organ Transplant. 2017 Feb;22(1):29-35. doi: 10.1097/MOT.0000000000000371.
PURPOSE OF REVIEW
To date, outcomes after lung transplantation are far worse than after transplantation of other solid organs. New insights into mechanisms that contribute to graft rejection and tolerance after lung transplantation remain of great interest. This review examines the recent literature on the role of innate and adaptive immunity in shaping the fate of lung grafts.
RECENT FINDINGS
Innate and adaptive immune cells orchestrate allograft rejection after transplantation. Innate immune cells such as neutrophils are recruited to the lung graft early after reperfusion and subsequently promote allograft rejection. Although it is widely recognized that CD4 T lymphocytes in concert with CD8 T cells promote graft rejection, regulatory Foxp3 CD4 T, central memory CD8 T cells, and natural killer cells can facilitate tolerance.
SUMMARY
This review highlights interactions between innate and adaptive immune pathways and how they contribute to lung allograft rejection. These findings lay a foundation for the design of new therapeutic strategies that target both innate and adaptive immune responses.
综述目的
迄今为止，肺移植后的结果远差于其他实体器官移植。对肺移植后导致移植物排斥和耐受的机制的新见解仍然备受关注。本综述探讨了近期关于固有免疫和适应性免疫在决定肺移植命运中作用的文献。
最新发现
固有免疫细胞和适应性免疫细胞在移植后协同引发同种异体移植物排斥。中性粒细胞等固有免疫细胞在再灌注后早期被募集到肺移植物中，随后促进同种异体移植物排斥。虽然人们普遍认识到CD4 T淋巴细胞与CD8 T细胞协同促进移植物排斥，但调节性Foxp3 CD4 T细胞、中枢记忆CD8 T细胞和自然杀伤细胞可促进耐受。
总结
本综述强调了固有免疫和适应性免疫途径之间的相互作用以及它们如何导致肺同种异体移植物排斥。这些发现为设计针对固有免疫和适应性免疫反应的新治疗策略奠定了基础。
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