一种用于双光子光动力疗法的谷胱甘肽可激活的钌（II）-偶氮光敏剂。
A GSH-activatable ruthenium(ii)-azo photosensitizer for two-photon photodynamic therapy.
作者信息
Zeng Leli, Kuang Shi, Li Guanying, Jin Chengzhi, Ji Liangnian, Chao Hui
机构信息
MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China.
出版信息
Chem Commun (Camb). 2017 Feb 7;53(12):1977-1980. doi: 10.1039/c6cc10330h.
PMID:28119967
Abstract
A glutathione (GSH)-activatable ruthenium(ii)-azo photosensitizer was prepared. The complex had low toxicity towards cells under dark conditions. It exhibited excellent phototoxicity under two-photon excitation (810 nm) and thus was developed as a two-photon photodynamic anticancer agent for cancer therapy.
摘要
制备了一种可被谷胱甘肽（GSH）激活的钌（II）-偶氮光敏剂。该配合物在黑暗条件下对细胞毒性较低。在双光子激发（810 nm）下表现出优异的光毒性，因此被开发为用于癌症治疗的双光子光动力抗癌剂。
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