慢性阻塞性肺疾病患者血浆白细胞介素-33水平相关因素
Factors associated with plasma IL-33 levels in patients with chronic obstructive pulmonary disease.
作者信息
Kim Sei Won, Rhee Chin Kook, Kim Ki Uk, Lee Sang Haak, Hwang Hun Gyu, Kim Yu Il, Kim Deog Kyeom, Lee Sang Do, Oh Yeon-Mok, Yoon Hyoung Kyu
机构信息
Division of Pulmonary, Department of Internal Medicine, Yeouido St Mary's Hospital.
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul.
出版信息
Int J Chron Obstruct Pulmon Dis. 2017 Jan 21;12:395-402. doi: 10.2147/COPD.S120445. eCollection 2017.
BACKGROUND
Interleukin (IL)-33 promotes T helper (Th)2 immunity and systemic inflammation. The role of IL-33 in asthma has been widely investigated. IL-33 has also been suggested to play an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). This study investigated the clinical significance and usefulness of plasma IL-33 level in patients with COPD.
METHODS
A total of 307 patients with stable COPD from 15 centers, who were in the Korean Obstructive Lung Disease cohort, were enrolled in this study. Plasma IL-33 levels were measured by enzyme-linked immunosorbent assay. We analyzed the association between IL-33 level and other clinical characteristics related to COPD. We also examined the features of patients with COPD who exhibited high IL-33 levels.
RESULTS
IL-33 levels varied, but were very low in most patients. Eosinophil count was significantly correlated with a plasma IL-33 level. In addition, old age and current smoking were related to a low IL-33 level. Significantly more patients with a higher IL-33 level had chronic bronchitis compared with those with a low IL-33 level.
CONCLUSION
Plasma IL-33 level in patients with stable COPD was related to eosinophil count and chronic bronchitis phenotype. Further studies are needed to identify the precise mechanisms of IL-33/ST2 pathway in patients with COPD.
背景
白细胞介素（IL）-33可促进辅助性T（Th）2免疫反应和全身炎症。IL-33在哮喘中的作用已得到广泛研究。也有研究表明IL-33在慢性阻塞性肺疾病（COPD）的发病机制中起重要作用。本研究旨在探讨COPD患者血浆IL-33水平的临床意义及应用价值。
方法
本研究纳入了韩国阻塞性肺病队列中15个中心的307例稳定期COPD患者。采用酶联免疫吸附测定法检测血浆IL-33水平。我们分析了IL-33水平与其他COPD相关临床特征之间的关联。我们还研究了IL-33水平高的COPD患者的特征。
结果
IL-33水平各不相同，但大多数患者的水平非常低。嗜酸性粒细胞计数与血浆IL-33水平显著相关。此外，老年和当前吸烟与低IL-33水平有关。与IL-33水平低的患者相比，IL-33水平高的患者患慢性支气管炎的比例明显更高。
结论
稳定期COPD患者的血浆IL-33水平与嗜酸性粒细胞计数和慢性支气管炎表型有关。需要进一步研究以确定COPD患者中IL-33/ST2途径的确切机制。
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