老年预期寿命决定因素中的性别差异：围绝经期的影响。
Sex-Based Differences in the Determinants of Old Age Life Expectancy: The Influence of Perimenopause.
作者信息
Falconi April M
机构信息
a School of Public Health, University of California, Berkeley , Berkeley , California.
出版信息
Biodemography Soc Biol. 2017;63(1):54-70. doi: 10.1080/19485565.2016.1273755.
Studies using the sensitive periods framework typically examine the effects of early life exposures on later life health, due to the significant growth and development occurring during the first few years of life. The menopausal transition (i.e., perimenopause) is similarly characterized by rapid physiological change, yet rarely has been tested as a sensitive window in adulthood. Cohort mortality data drawn from three historic populations, Sweden (1751-1919), France (1816-1919), and England and Wales (1841-1919), were analyzed using time series methods to assess whether conditions at midlife significantly influenced or "programmed" later life longevity. Results indicated a significant inverse association between mortality at ages 45-49, the average age range in which perimenopause occurred, and life expectancy at age 60 among females in all three countries. Study findings suggest a degree of plasticity associated with women's aging and, in particular, the age group correlated with perimenopause.
由于生命最初几年会发生显著的生长和发育，使用敏感期框架的研究通常会考察早年暴露对晚年健康的影响。更年期过渡（即围绝经期）同样以快速的生理变化为特征，但很少被作为成年期的一个敏感窗口进行测试。利用时间序列方法分析了来自瑞典（1751 - 1919年）、法国（1816 - 1919年）以及英格兰和威尔士（1841 - 1919年）这三个历史人口群体的队列死亡率数据，以评估中年时期的状况是否会显著影响或“设定”晚年的寿命。结果表明，在所有三个国家的女性中，45 - 49岁（围绝经期发生的平均年龄范围）的死亡率与60岁时的预期寿命之间存在显著的负相关。研究结果表明女性衰老具有一定程度的可塑性，特别是与围绝经期相关的年龄组。
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