多形性胶质母细胞瘤：诊断与治疗；近期文献综述
Glioblastoma Multiforme, Diagnosis and Treatment; Recent Literature Review.
作者信息
Batash Ron, Asna Noam, Schaffer Pamela, Francis Nicole, Schaffer Moshe
机构信息
Barzilai Medical Center, Department of Orthopedic Surgery, Ashkelon. Israel.
Barzilai Medical Center, Department of Oncology, Ashkelon. Israel.
出版信息
Curr Med Chem. 2017;24(27):3002-3009. doi: 10.2174/0929867324666170516123206.
BACKGROUND
Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor, with an incidence of 3.19 cases per 100,000 person years and remarkably poor prognosis showing a 5-year survival rate of 4-5%, and only a 26-33% survival rate at 2 years in clinical trials.
OBJECTIVE
In this paper, we review the different types of treatment modalities based on the relevant databases. Methods of diagnosis will be described briefly.
METHOD
Systemic compilation of the relevant literature.
RESULTS & CONCLUSION: Today's treatments cannot cure GBM patients but only extend their overall survival. The use of chemoradiation, immunotherapy, and radio sensitizers as an adjuvant therapy cannot reduce the high rates of recurrence within a few months after treatment. Radiotherapy will remain the backbone of the treatment but new treatment modalities must be developed.
背景
多形性胶质母细胞瘤（GBM）是最常见的原发性恶性脑肿瘤，发病率为每10万人年3.19例，预后极差，5年生存率为4 - 5%，在临床试验中2年生存率仅为26 - 33%。
目的
在本文中，我们基于相关数据库综述不同类型的治疗方式。将简要描述诊断方法。
方法
对相关文献进行系统汇编。
结果与结论
目前的治疗方法无法治愈GBM患者，只能延长其总生存期。使用放化疗、免疫疗法和放射增敏剂作为辅助治疗并不能降低治疗后几个月内的高复发率。放疗仍将是治疗的主要手段，但必须开发新的治疗方式。
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