癌症微环境中的趋化因子及其在癌症免疫治疗中的相关性。
Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy.
作者信息
Nagarsheth Nisha, Wicha Max S, Zou Weiping
机构信息
Department of Surgery, University of Michigan School of Medicine, 109 Zina Pitcher Place, Ann Arbor, Michigan 48109, USA.
Graduate Programs in Immunology and Tumour Biology, University of Michigan, Ann Arbor, Michigan 48109, USA.
出版信息
Nat Rev Immunol. 2017 Sep;17(9):559-572. doi: 10.1038/nri.2017.49. Epub 2017 May 30.
The tumour microenvironment is the primary location in which tumour cells and the host immune system interact. Different immune cell subsets are recruited into the tumour microenvironment via interactions between chemokines and chemokine receptors, and these populations have distinct effects on tumour progression and therapeutic outcomes. In this Review, we focus on the main chemokines that are found in the human tumour microenvironment; we elaborate on their patterns of expression, their regulation and their roles in immune cell recruitment and in cancer and stromal cell biology, and we consider how they affect cancer immunity and tumorigenesis. We also discuss the potential of targeting chemokine networks, in combination with other immunotherapies, for the treatment of cancer.
肿瘤微环境是肿瘤细胞与宿主免疫系统相互作用的主要场所。不同的免疫细胞亚群通过趋化因子与趋化因子受体之间的相互作用被募集到肿瘤微环境中，这些细胞群体对肿瘤进展和治疗结果具有不同的影响。在本综述中，我们聚焦于人类肿瘤微环境中发现的主要趋化因子；详细阐述它们的表达模式、调控机制及其在免疫细胞募集以及癌症和基质细胞生物学中的作用，并探讨它们如何影响癌症免疫和肿瘤发生。我们还讨论了联合其他免疫疗法靶向趋化因子网络用于癌症治疗的潜力。
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