肿瘤微环境中的代谢重编程：癌细胞与T淋巴细胞的共同特征。
Metabolic reprogramming in the tumour microenvironment: a hallmark shared by cancer cells and T lymphocytes.
作者信息
Allison Katrina E, Coomber Brenda L, Bridle Byram W
机构信息
Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.
Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.
出版信息
Immunology. 2017 Oct;152(2):175-184. doi: 10.1111/imm.12777. Epub 2017 Jul 10.
Abstract
Altered metabolism is a hallmark of cancers, including shifting oxidative phosphorylation to glycolysis and up-regulating glutaminolysis to divert carbon sources into biosynthetic pathways that promote proliferation and survival. Therefore, metabolic inhibitors represent promising anti-cancer drugs. However, T cells must rapidly divide and survive in harsh microenvironments to mediate anti-cancer effects. Metabolic profiles of cancer cells and activated T lymphocytes are similar, raising the risk of metabolic inhibitors impairing the immune system. Immune checkpoint blockade provides an example of how metabolism can be differentially impacted to impair cancer cells but support T cells. Implications for research with metabolic inhibitors are discussed.
摘要
代谢改变是癌症的一个标志，包括将氧化磷酸化转变为糖酵解以及上调谷氨酰胺分解，从而将碳源转移到促进增殖和存活的生物合成途径中。因此，代谢抑制剂是很有前景的抗癌药物。然而，T细胞必须在恶劣的微环境中快速分裂并存活，以介导抗癌作用。癌细胞和活化T淋巴细胞的代谢特征相似，这增加了代谢抑制剂损害免疫系统的风险。免疫检查点阻断提供了一个例子，说明如何对代谢产生不同的影响，以损害癌细胞但支持T细胞。本文讨论了代谢抑制剂研究的意义。
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