Downregulation of MicroRNA-126 Augments DNA Damage Response in Cigarette Smokers and Patients with Chronic Obstructive Pulmonary Disease.
作者信息
Paschalaki Koralia E, Zampetaki Anna, Baker Jonathan R, Birrell Mark A, Starke Richard D, Belvisi Maria G, Donnelly Louise E, Mayr Manuel, Randi Anna M, Barnes Peter J
机构信息
1 Imperial College London London, United Kingdom and.
2 King's College London British Heart Foundation Centre of Research Excellence London, United Kingdom.
出版信息
Am J Respir Crit Care Med. 2018 Mar 1;197(5):665-668. doi: 10.1164/rccm.201706-1304LE.
Abstract
摘要
相似文献
1
Downregulation of MicroRNA-126 Augments DNA Damage Response in Cigarette Smokers and Patients with Chronic Obstructive Pulmonary Disease.
Am J Respir Crit Care Med. 2018 Mar 1;197(5):665-668. doi: 10.1164/rccm.201706-1304LE.
2
MicroRNA miR-24-3p reduces DNA damage responses, apoptosis, and susceptibility to chronic obstructive pulmonary disease.
JCI Insight. 2021 Jan 25;6(2):134218. doi: 10.1172/jci.insight.134218.
3
microRNA profiling in lung tissue and bronchoalveolar lavage of cigarette smoke-exposed mice and in COPD patients: a translational approach.
Sci Rep. 2017 Oct 9;7(1):12871. doi: 10.1038/s41598-017-13265-8.
4
Lung DNA Methylation in Chronic Obstructive Pulmonary Disease: Relationship with Smoking Status and Airflow Limitation Severity.
Am J Respir Crit Care Med. 2021 Jan 1;203(1):129-134. doi: 10.1164/rccm.201912-2420LE.
5
Expression of long non-coding RNA LUCAT1 in patients with chronic obstructive pulmonary disease and its potential functions in regulating cigarette smoke extract-induced 16HBE cell proliferation and apoptosis.
J Clin Lab Anal. 2021 Jul;35(7):e23823. doi: 10.1002/jcla.23823. Epub 2021 Jun 14.
6
Decreased miR-29b expression is associated with airway inflammation in chronic obstructive pulmonary disease.
Am J Physiol Lung Cell Mol Physiol. 2019 Apr 1;316(4):L621-L629. doi: 10.1152/ajplung.00436.2018. Epub 2019 Jan 17.
7
Effect of a single nucleotide polymorphism in miR-146a on COX-2 protein expression and lung function in smokers with chronic obstructive pulmonary disease.
Int J Chron Obstruct Pulmon Dis. 2015 Mar 4;10:463-73. doi: 10.2147/COPD.S74345. eCollection 2015.
8
MicroRNA Profiling Reveals a Role for MicroRNA-218-5p in the Pathogenesis of Chronic Obstructive Pulmonary Disease.
Am J Respir Crit Care Med. 2017 Jan 1;195(1):43-56. doi: 10.1164/rccm.201506-1182OC.
9
Role of CXCL13 in cigarette smoke-induced lymphoid follicle formation and chronic obstructive pulmonary disease.
Am J Respir Crit Care Med. 2013 Aug 1;188(3):343-55. doi: 10.1164/rccm.201211-2055OC.
10
An increased ratio of serum miR-21 to miR-181a levels is associated with the early pathogenic process of chronic obstructive pulmonary disease in asymptomatic heavy smokers.
Mol Biosyst. 2014 May;10(5):1072-81. doi: 10.1039/c3mb70564a.
引用本文的文献
1
Transcriptomic Profiling of Mouse Mesenchymal Stem Cells Exposed to Metal-Based Nanoparticles.
Int J Mol Sci. 2025 Aug 5;26(15):7583. doi: 10.3390/ijms26157583.
2
Isolation and Characterization of Endothelial-Colony Forming Cells (ECFC): Studying Endothelial Senescence for Translational Studies and for Personalized Medicine.
Methods Mol Biol. 2025;2906:255-270. doi: 10.1007/978-1-0716-4426-3_15.
3
Discovering the role of microRNAs and exosomal microRNAs in chest and pulmonary diseases: a spotlight on chronic obstructive pulmonary disease.
Mol Genet Genomics. 2024 Nov 11;299(1):107. doi: 10.1007/s00438-024-02199-2.
4
MicroRNAs as promising drug delivery target to ameliorate chronic obstructive pulmonary disease using nano-carriers: a comprehensive review.
Mol Cell Biochem. 2025 Mar;480(3):1431-1448. doi: 10.1007/s11010-024-05110-0. Epub 2024 Sep 10.
5
Mechanisms Contributing to the Comorbidity of COPD and Lung Cancer.
Int J Mol Sci. 2023 Feb 2;24(3):2859. doi: 10.3390/ijms24032859.
6
Characterization of pulmonary vascular remodeling and MicroRNA-126-targets in COPD-pulmonary hypertension.
Respir Res. 2022 Dec 15;23(1):349. doi: 10.1186/s12931-022-02267-4.
7
Pathological Roles for Endothelial Colony-Forming Cells in Neonatal and Adult Lung Disease.
Am J Respir Cell Mol Biol. 2023 Jan;68(1):13-22. doi: 10.1165/rcmb.2022-0318PS.
8
Expression and Related Mechanisms of miR-100 and TRIB2 in COPD Patients.
J Healthc Eng. 2022 Apr 21;2022:6556208. doi: 10.1155/2022/6556208. eCollection 2022.
9
Human Endothelial Colony-Forming Cells.
Cold Spring Harb Perspect Med. 2022 Dec 1;12(12):a041154. doi: 10.1101/cshperspect.a041154.
10
Inhaled corticosteroids reduce senescence in endothelial progenitor cells from patients with COPD.
Thorax. 2022 Jun;77(6):616-620. doi: 10.1136/thoraxjnl-2020-216807. Epub 2022 Jan 13.
本文引用的文献
1
Oxidative stress dependent microRNA-34a activation via PI3Kα reduces the expression of sirtuin-1 and sirtuin-6 in epithelial cells.
Sci Rep. 2016 Oct 21;6:35871. doi: 10.1038/srep35871.
2
Cellular senescence in aging and age-related disease: from mechanisms to therapy.
Nat Med. 2015 Dec;21(12):1424-35. doi: 10.1038/nm.4000.
3
Downregulation of MicroRNA-126 Contributes to the Failing Right Ventricle in Pulmonary Arterial Hypertension.
Circulation. 2015 Sep 8;132(10):932-43. doi: 10.1161/CIRCULATIONAHA.115.016382. Epub 2015 Jul 10.
4
miR-126 in human cancers: clinical roles and current perspectives.
Exp Mol Pathol. 2014 Feb;96(1):98-107. doi: 10.1016/j.yexmp.2013.12.004. Epub 2013 Dec 22.
5
Endothelial microparticle-mediated transfer of MicroRNA-126 promotes vascular endothelial cell repair via SPRED1 and is abrogated in glucose-damaged endothelial microparticles.
Circulation. 2013 Oct 29;128(18):2026-38. doi: 10.1161/CIRCULATIONAHA.113.001720. Epub 2013 Sep 6.
6
Dysfunction of endothelial progenitor cells from smokers and chronic obstructive pulmonary disease patients due to increased DNA damage and senescence.
Stem Cells. 2013 Dec;31(12):2813-26. doi: 10.1002/stem.1488.
7
DNA damage as a molecular link in the pathogenesis of COPD in smokers.
Eur Respir J. 2012 Jun;39(6):1368-76. doi: 10.1183/09031936.00050211. Epub 2012 Jan 20.
8
P2X7 receptor and caspase 1 activation are central to airway inflammation observed after exposure to tobacco smoke.
PLoS One. 2011;6(9):e24097. doi: 10.1371/journal.pone.0024097. Epub 2011 Sep 6.
9
Plasma microRNA profiling reveals loss of endothelial miR-126 and other microRNAs in type 2 diabetes.
Circ Res. 2010 Sep 17;107(6):810-7. doi: 10.1161/CIRCRESAHA.110.226357. Epub 2010 Jul 22.
10
miR-126 regulates angiogenic signaling and vascular integrity.
Dev Cell. 2008 Aug;15(2):272-84. doi: 10.1016/j.devcel.2008.07.008.
Zotero 插件