TMPRSS2：抗流感病毒和冠状病毒感染治疗的潜在靶标。
TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections.
机构信息
Lab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Institute of Drug Development & Chemical Biology, Zhejiang University of Technology, Hangzhou, 310014, China.
Lab of Molecular Immunology, Virus Inspection Department, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, 310051, China.
出版信息
Biochimie. 2017 Nov;142:1-10. doi: 10.1016/j.biochi.2017.07.016. Epub 2017 Aug 1.
Influenza virus and coronavirus epidemics or pandemics have occurred in succession worldwide throughout the early 21st century. These epidemics or pandemics pose a major threat to human health. Here, we outline a critical role of the host cell protease TMPRSS2 in influenza virus and coronavirus infections and highlight an antiviral therapeutic strategy targeting TMPRSS2.
21 世纪初，流感病毒和冠状病毒在全球范围内相继爆发流行。这些大流行对人类健康构成了重大威胁。在这里，我们概述了宿主细胞蛋白酶 TMPRSS2 在流感病毒和冠状病毒感染中的关键作用，并强调了针对 TMPRSS2 的抗病毒治疗策略。
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