分化细胞中的微管组织、动力学及功能
Microtubule organization, dynamics and functions in differentiated cells.
作者信息
Muroyama Andrew, Lechler Terry
机构信息
Departments of Dermatology and Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.
Departments of Dermatology and Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
出版信息
Development. 2017 Sep 1;144(17):3012-3021. doi: 10.1242/dev.153171.
Over the past several decades, numerous studies have greatly expanded our knowledge about how microtubule organization and dynamics are controlled in cultured cells However, our understanding of microtubule dynamics and functions , in differentiated cells and tissues, remains under-explored. Recent advances in generating genetic tools and imaging technologies to probe microtubules , coupled with an increased interest in the functions of this cytoskeletal network in differentiated cells, are resulting in a renaissance. Here, we discuss the lessons learned from such approaches, which have revealed that, although some differentiated cells utilize conserved strategies to remodel microtubules, there is considerable diversity in the underlying molecular mechanisms of microtubule reorganization. This highlights a continued need to explore how differentiated cells regulate microtubule geometry .
在过去几十年中，大量研究极大地扩展了我们对培养细胞中微管组织和动力学如何受到控制的认识。然而，我们对分化细胞和组织中微管动力学及功能的理解仍有待深入探索。用于探测微管的遗传工具和成像技术的最新进展，再加上对这个细胞骨架网络在分化细胞中功能的兴趣增加，正带来一场复兴。在这里，我们讨论从这些方法中学到的经验教训，这些经验教训表明，尽管一些分化细胞利用保守策略重塑微管，但微管重组的潜在分子机制存在相当大的差异。这突出表明持续需要探索分化细胞如何调节微管几何形状。
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