囊性纤维化患者亚极量踏车运动时的血流调节和氧化应激。
Blood flow regulation and oxidative stress during submaximal cycling exercise in patients with cystic fibrosis.
机构信息
Georgia Prevention Institute, Augusta University, Augusta, GA, United States.
Sport and Exercise Sciences Research Institute, Ulster University, Jordanstown, Northern Ireland, United Kingdom.
出版信息
J Cyst Fibros. 2018 Mar;17(2):256-263. doi: 10.1016/j.jcf.2017.08.015. Epub 2017 Oct 12.
BACKGROUND
The impact of blood flow regulation and oxidative stress during exercise in cystic fibrosis (CF) has yet to be investigated.
METHODS
A maximal graded exercise test was conducted to determine exercise capacity (VO peak) and peak workload in 14 pediatric patients with mild CF (age 14±3y, FEV 93±16 % predicted) and 14 demographically-matched controls. On a separate visit, participants performed submaximal cycling up to 60% of peak workload where brachial artery blood velocity was determined using Doppler ultrasound. Retrograde and antegrade components were further analyzed as indices of blood flow regulation.
RESULTS
The cumulative AUC for retrograde velocity was lower in patients versus controls (1770±554 vs. 3440±522cm, P=0.038). In addition, an exaggerated oxidative stress response during exercise occurred in patients only (P=0.004).
CONCLUSION
These data suggest that patients with mild CF exhibit impaired blood flow regulation and an exaggerated oxidative stress response to submaximal exercise.
背景
在囊性纤维化（CF）患者运动期间，血流调节和氧化应激的影响尚未得到研究。
方法
对 14 名轻度 CF 患儿（年龄 14±3 岁，FEV1 预测值的 93±16%）和 14 名匹配的对照者进行最大分级运动试验，以确定运动能力（峰值摄氧量 VOpeak）和峰值工作负荷。在另一次访问中，参与者以 60%的峰值工作负荷进行次最大循环运动，使用多普勒超声测量肱动脉血流速度。进一步分析逆行和前向分量作为血流调节的指标。
结果
与对照组相比，患者的逆行速度累积 AUC 较低（1770±554 对 3440±522cm，P=0.038）。此外，只有患者在运动期间发生了过度的氧化应激反应（P=0.004）。
结论
这些数据表明，轻度 CF 患者表现出血流调节受损和亚最大运动时氧化应激反应过度。
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