秀丽隐杆线虫作为病毒-宿主相互作用的新兴模型
Caenorhabditis elegans as an Emerging Model for Virus-Host Interactions.
作者信息
Gammon Don B
机构信息
Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
出版信息
J Virol. 2017 Nov 14;91(23). doi: 10.1128/JVI.00509-17. Print 2017 Dec 1.
Abstract
Since 1999, has been extensively used to study microbe-host interactions due to its simple culture, genetic tractability, and susceptibility to numerous bacterial and fungal pathogens. In contrast, virus studies have been hampered by a lack of convenient virus infection models in nematodes. The recent discovery of a natural viral pathogen of and development of diverse artificial infection models are providing new opportunities to explore virus-host interplay in this powerful model organism.
摘要
自1999年以来，由于其培养简单、遗传易处理且对多种细菌和真菌病原体敏感，已被广泛用于研究微生物与宿主的相互作用。相比之下，线虫中缺乏便捷的病毒感染模型阻碍了病毒研究。最近发现的一种天然病毒病原体以及多种人工感染模型的开发，为在这种强大的模式生物中探索病毒与宿主的相互作用提供了新机会。
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