转移抑制因子：功能途径。
Metastasis suppressors: functional pathways.
机构信息
Women's Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
出版信息
Lab Invest. 2018 Feb;98(2):198-210. doi: 10.1038/labinvest.2017.104. Epub 2017 Oct 2.
Abstract
Metastasis is a complex process and a major contributor of death in cancer patients. Metastasis suppressor genes are identified by their ability to inhibit metastasis at a secondary site without affecting the growth of primary tumor. In this review, we have conducted a survey of the metastasis suppressor literature to identify common downstream pathways. The metastasis suppressor genes mechanistically target MAPK, G-protein-coupled receptor, cell adhesion, cytoskeletal, transcriptional regulatory, and metastasis susceptibility pathways. The majority of the metastasis suppressor genes are functionally multifactorial, inhibiting metastasis at multiple points in the cascade, and many operate in a context-dependent fashion. A greater understanding of common pathways/molecules targeted by metastasis suppressor could improve metastasis treatment strategies.
摘要
转移是一个复杂的过程，也是癌症患者死亡的主要原因。转移抑制基因是通过抑制次级部位的转移而不影响原发性肿瘤的生长来识别的。在这篇综述中，我们对转移抑制基因文献进行了调查，以确定常见的下游途径。转移抑制基因在机制上靶向 MAPK、G 蛋白偶联受体、细胞黏附、细胞骨架、转录调控和转移易感性途径。大多数转移抑制基因在功能上是多因素的，在级联的多个点抑制转移，许多基因以依赖于上下文的方式发挥作用。对转移抑制因子靶向的共同途径/分子的进一步了解可能会改善转移的治疗策略。
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本文引用的文献
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Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1072-E1080. doi: 10.1073/pnas.1613091114. Epub 2017 Jan 30.
2
Favorable prognosis in colorectal cancer patients with co-expression of c-MYC and ß-catenin.
BMC Cancer. 2016 Sep 13;16(1):730. doi: 10.1186/s12885-016-2770-7.
3
C-myc overexpression drives melanoma metastasis by promoting vasculogenic mimicry via c-myc/snail/Bax signaling.
J Mol Med (Berl). 2017 Jan;95(1):53-67. doi: 10.1007/s00109-016-1452-x. Epub 2016 Aug 19.
4
Gas1 Inhibits Metastatic and Metabolic Phenotypes in Colorectal Carcinoma.
Mol Cancer Res. 2016 Sep;14(9):830-40. doi: 10.1158/1541-7786.MCR-16-0032. Epub 2016 Jul 11.
5
MYC Is a Crucial Mediator of TGFβ-Induced Invasion in Basal Breast Cancer.
Cancer Res. 2016 Jun 15;76(12):3520-30. doi: 10.1158/0008-5472.CAN-15-3465. Epub 2016 Apr 13.
6
An Integrated Genome-Wide Systems Genetics Screen for Breast Cancer Metastasis Susceptibility Genes.
PLoS Genet. 2016 Apr 13;12(4):e1005989. doi: 10.1371/journal.pgen.1005989. eCollection 2016 Apr.
7
Myc coordinates transcription and translation to enhance transformation and suppress invasiveness.
EMBO Rep. 2015 Dec;16(12):1723-36. doi: 10.15252/embr.201540717. Epub 2015 Nov 4.
8
Rho1-Wnd signaling regulates loss-of-cell polarity-induced cell invasion in Drosophila.
Oncogene. 2016 Feb 18;35(7):846-55. doi: 10.1038/onc.2015.137. Epub 2015 May 11.
9
A cytoplasmic NF-κB interacting long noncoding RNA blocks IκB phosphorylation and suppresses breast cancer metastasis.
Cancer Cell. 2015 Mar 9;27(3):370-81. doi: 10.1016/j.ccell.2015.02.004.
10
Raf kinase inhibitory protein (RKIP) as a metastasis suppressor: regulation of signaling networks in cancer.
Crit Rev Oncog. 2014;19(6):447-54. doi: 10.1615/critrevoncog.2014012000.
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