Wu S S, Sun F, Zhan S Y
National Clinical Research Center of Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China; Center of Evidence-Based Medicine and Clinical Research, Peking University, Beijing 100191, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2017 Oct 10;38(10):1436-1440. doi: 10.3760/cma.j.issn.0254-6450.2017.10.028.
This paper introduces the revised Cochrane bias risk assessment tool for individual randomized, cross-over trials (RoB2.0), comparing RoB2.0 of cross-over design with RoB2.0 of parallel design, and illustrating the application of RoB2.0 for cross-over trials in a published clinical trial. As a comprehensive tool specially designed for cross-over design, it provides more information on risk of bias in systematic reviews for the evidence synthesis.
本文介绍了针对个体随机交叉试验的修订版Cochrane偏倚风险评估工具(RoB2.0),比较了交叉设计的RoB2.0与平行设计的RoB2.0,并在一项已发表的临床试验中说明了RoB2.0在交叉试验中的应用。作为专门为交叉设计设计的综合工具,它为证据综合的系统评价提供了更多关于偏倚风险的信息。