腺苷蛋氨酸治疗丙型肝炎病毒表达：需要考虑腺苷蛋氨酸的化学、生理和药代动力学。
-Adenosyl-L-methionine towards hepatitis C virus expression: Need to consider -Adenosyl-L-methionine's chemistry, physiology and pharmacokinetics.
机构信息
Core Unit Proteomics, Hannover Medical School, Hannover 30623, Germany.
出版信息
World J Gastroenterol. 2017 Oct 28;23(40):7343-7346. doi: 10.3748/wjg.v23.i40.7343.
Abstract
-Adenosyl-L-methionine (SAM) is a cofactor serving as a methyl donor in numerous enzymatic reactions. It has been reported that SAM has the potential to modify antioxidant-enzymes, glutathione-biosynthesis and methionine adenosyltransferases-1/2 in hepatitis C virus -expressing cells at millimolar concentrations. The efficacy of SAM at micromolar concentrations and the underlying mechanisms remain to be demonstrated.
摘要
腺苷-L-蛋氨酸（SAM）是一种辅因子，作为甲基供体在许多酶反应中发挥作用。据报道，SAM 有潜力在毫摩尔浓度下修饰丙型肝炎病毒表达细胞中的抗氧化酶、谷胱甘肽生物合成和蛋氨酸腺苷转移酶 1/2。SAM 在微摩尔浓度下的疗效及其潜在机制仍有待证明。
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本文引用的文献
1
Spontaneous Emergence of S-Adenosylmethionine and the Evolution of Methylation.
Angew Chem Int Ed Engl. 2017 Jan 2;56(1):343-345. doi: 10.1002/anie.201609615. Epub 2016 Nov 30.
2
Consensus recommendations for the diagnosis, treatment and follow-up of inherited methylation disorders.
J Inherit Metab Dis. 2017 Jan;40(1):5-20. doi: 10.1007/s10545-016-9972-7. Epub 2016 Sep 26.
3
S-adenosyl-L-methionine modifies antioxidant-enzymes, glutathione-biosynthesis and methionine adenosyltransferases-1/2 in hepatitis C virus-expressing cells.
World J Gastroenterol. 2016 Apr 14;22(14):3746-57. doi: 10.3748/wjg.v22.i14.3746.
4
Role of S-adenosylhomocysteine in cardiovascular disease and its potential epigenetic mechanism.
Int J Biochem Cell Biol. 2015 Oct;67:158-66. doi: 10.1016/j.biocel.2015.06.015. Epub 2015 Jun 24.
5
S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis.
PLoS One. 2015 Mar 16;10(3):e0122124. doi: 10.1371/journal.pone.0122124. eCollection 2015.
6
Methylselenol formed by spontaneous methylation of selenide is a superior selenium substrate to the thioredoxin and glutaredoxin systems.
PLoS One. 2012;7(11):e50727. doi: 10.1371/journal.pone.0050727. Epub 2012 Nov 30.
7
S-adenosyl methionine improves early viral responses and interferon-stimulated gene induction in hepatitis C nonresponders.
Gastroenterology. 2011 Mar;140(3):830-9. doi: 10.1053/j.gastro.2010.09.010. Epub 2010 Sep 17.
8
Simultaneous quantification of S-adenosyl methionine and S-adenosyl homocysteine in human plasma by stable-isotope dilution ultra performance liquid chromatography tandem mass spectrometry.
J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Nov 15;877(30):3865-70. doi: 10.1016/j.jchromb.2009.09.039. Epub 2009 Sep 30.
9
Sources of S-adenosyl-L-homocysteine background in measuring protein arginine N-methyltransferase activity using tandem mass spectrometry.
Anal Biochem. 2010 Jan 1;396(1):158-60. doi: 10.1016/j.ab.2009.08.043. Epub 2009 Sep 3.
10
Determination of S-Adenosylmethionine and S-Adenosylhomocysteine by LC-MS/MS and evaluation of their stability in mice tissues.
J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jul 15;877(22):2061-6. doi: 10.1016/j.jchromb.2009.05.039. Epub 2009 May 28.
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