14-3-3蛋白：疾病中自噬的重要调节因子。
14-3-3 proteins: an important regulator of autophagy in diseases.
作者信息
Jia Haoyuan, Liang Zhaofeng, Zhang Xu, Wang Juanjuan, Xu Wenrong, Qian Hui
机构信息
Key Laboratory of Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu UniversityZhenjiang, Jiangsu, P. R. China.
Wuxi People's Hospital Affiliated to Nanjing Medical UniversityWuxi 214023, Jiangsu, China.
出版信息
Am J Transl Res. 2017 Nov 15;9(11):4738-4746. eCollection 2017.
Abstract
Autophagy is a cell digestion process that determines cell fate by promoting cell survival or inducing cell death in a cell context-dependent manner. Several classical signaling pathways, such as phosphoinositide-3-kinase and mammalian target of rapamycin, tightly regulate autophagy. 14-3-3 proteins regulate various signaling pathways by phosphorylation-dependent binding with partner proteins. 14-3-3 proteins also regulate autophagy by binding with autophagy-related proteins such as Beclin-1 and hVPS34. This review summarizes the role of 14-3-3 proteins in the control of autophagy in cancer, neurodegenerative diseases and other pathological conditions.
摘要
自噬是一种细胞消化过程，它通过以细胞环境依赖的方式促进细胞存活或诱导细胞死亡来决定细胞命运。几种经典的信号通路，如磷酸肌醇-3-激酶和雷帕霉素哺乳动物靶点，紧密调节自噬。14-3-3蛋白通过与伴侣蛋白的磷酸化依赖性结合来调节各种信号通路。14-3-3蛋白还通过与自噬相关蛋白如Beclin-1和hVPS34结合来调节自噬。本综述总结了14-3-3蛋白在癌症、神经退行性疾病和其他病理状况下自噬调控中的作用。
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