巨噬细胞在眼内新生血管疾病中的多种作用：综述
Diverse roles of macrophages in intraocular neovascular diseases: a review.
作者信息
Zhou Ye-Di, Yoshida Shigeo, Peng Ying-Qian, Kobayashi Yoshiyuki, Zhang Lu-Si, Tang Luo-Sheng
机构信息
Department of Ophthalmology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China.
Hunan Clinical Research Center of Ophthalmic Disease, Changsha 410011, Hunan Province, China.
出版信息
Int J Ophthalmol. 2017 Dec 18;10(12):1902-1908. doi: 10.18240/ijo.2017.12.18. eCollection 2017.
Macrophages are involved in angiogenesis, and might also contribute to the pathogenesis of intraocular neovascular diseases. Recent studies indicated that macrophages exert different functions in the process of intraocular neovascularization, and the polarization of M1 and M2 phenotypes plays extremely essential roles in the diverse functions of macrophages. Moreover, a large number of cytokines released by macrophages not only participate in macrophage polarization, but also associate with retinal and choroidal neovascular diseases. Therefore, macrophage might be considered as a novel therapeutic target to the treatment of pathological neovascularization in the eye. This review mainly summarizes diverse roles of macrophages and discusses the possible mechanisms in retinal and choroidal neovascularization.
巨噬细胞参与血管生成，也可能在眼内新生血管疾病的发病机制中起作用。最近的研究表明，巨噬细胞在眼内新生血管形成过程中发挥不同功能，M1和M2表型的极化在巨噬细胞的多种功能中起着极其重要的作用。此外，巨噬细胞释放的大量细胞因子不仅参与巨噬细胞极化，还与视网膜和脉络膜新生血管疾病相关。因此，巨噬细胞可能被视为治疗眼部病理性新生血管的新治疗靶点。本综述主要总结巨噬细胞的不同作用，并探讨视网膜和脉络膜新生血管形成的可能机制。
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