不对称催化制备多取代环丙醇和环丙胺衍生物。
Asymmetric Catalytic Preparation of Polysubstituted Cyclopropanol and Cyclopropylamine Derivatives.
机构信息
The Mallat Family Laboratory of Organic Chemistry, Schulich Faculty of Chemistry, Technion-Israel Institute of Technology, Haifa, 3200009, Israel.
出版信息
Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1543-1546. doi: 10.1002/anie.201710707. Epub 2018 Jan 10.
PMID:29320599
Abstract
The catalytic asymmetric carbometalation of cyclopropenes followed by either an electrophilic oxidation or amination reaction provides a unique approach to the formation of diastereomerically pure and enantiomerically enriched cyclopropanol and cyclopropylamine derivatives, respectively.
摘要
环丙烯的催化不对称碳金属化反应，随后进行亲电氧化或氨化反应，分别为形成非对映异构体纯和对映体富集的环丙醇和环丙胺衍生物提供了一种独特的方法。
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