白色念珠菌种内多样性对真菌与宿主相互作用的调节
Modulation of the Fungal-Host Interaction by the Intra-Species Diversity of C. albicans.
作者信息
Braunsdorf Christina, LeibundGut-Landmann Salomé
机构信息
Section of Immunology, Vetsuisse Faculty, University of Zürich, Winterthurerstrasse 266a, CH-8057 Zürich, Switzerland.
出版信息
Pathogens. 2018 Jan 17;7(1):11. doi: 10.3390/pathogens7010011.
The incidence of human infections caused by the opportunistic fungal pathogen is on the rise due to increasing numbers of immunosuppressed patients. The importance of the immune system in preventing overgrowth of the colonizing fungus and thereby limiting infection is well recognized and host protective mechanisms widely investigated. Only recently, it was recognized that the natural diversity in the fungal species could also influence the outcome of the interaction between the fungus and the host. strain-specific differences are complex and their regulation at the genomic, genetic, and epigenetic level and by environmental factors is only partially understood. In this review, we provide an overview of the natural diversity of and discuss how it impacts host-fungal interactions and thereby affects the balance between commensalism versus disease.
由于免疫抑制患者数量的增加，由机会性真菌病原体引起的人类感染发生率正在上升。免疫系统在预防定殖真菌过度生长从而限制感染方面的重要性已得到广泛认可，并且对宿主保护机制也进行了广泛研究。直到最近，人们才认识到真菌物种的自然多样性也可能影响真菌与宿主之间相互作用的结果。菌株特异性差异很复杂，其在基因组、遗传和表观遗传水平以及环境因素的调控仅得到部分理解。在本综述中，我们概述了[真菌名称未给出]的自然多样性，并讨论了它如何影响宿主 - 真菌相互作用，从而影响共生与疾病之间的平衡。
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