In vitro studies of the antibacterial activity of spp. oleoresins, sodium hypochlorite, and peracetic acid against clinical and environmental isolates recovered from a hemodialysis unit.

BACKGROUND

Patients submitted to hemodialysis therapy are more susceptible to infection, especially to infection by Gram-positive bacteria. Various research works have attempted to discover new antimicrobial agents from plant extracts and other natural products.

METHODS

The present study aimed to assess the antibacterial activities of , , and oleoresins; sodium hypochlorite; and peracetic acid against clinical and environmental isolates recovered from a Hemodialysis Unit. The Minimum Inhibitory Concentration and the Fractionated Inhibitory Concentration Index were determined; the ability of the tested compounds/extracts to inhibit biofilm formation was evaluated by calculating the MICB and IC.

RESULTS

was the most efficient among the assayed species, and its oleoresin was more effective than peracetic acid and sodium hypochlorite. oleoresins and disinfectants did not act synergistically at any of the tested combinations. Certain of oleoresin, peracetic acid, and sodium hypochlorite concentrations inhibited biofilm formation and eradicated 50% of the biofilm population.

CONCLUSION

oleoresin is a potential candidate for disinfectant formulations. Based on these results and given the high incidence of multi-resistant bacteria in hemodialysis patients, it is imperative that new potential antibacterial agents like oleoresin, which is active against , be included in disinfectant formulations.