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妊娠改变女性的肾脏和汞的血液负担。

Pregnancy Alters Renal and Blood Burden of Mercury in Females.

机构信息

Department of Biomedical Sciences, Mercer University School of Medicine, 1501 College St, Macon, GA, 31207, USA.

出版信息

Biol Trace Elem Res. 2018 Nov;186(1):9-11. doi: 10.1007/s12011-018-1278-1. Epub 2018 Feb 24.

DOI:10.1007/s12011-018-1278-1
PMID:29478229
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6943925/
Abstract

Methylmercury (CHHg), a common environmental toxicant, has serious detrimental effects in numerous organ systems. We hypothesize that a significant physiological change, like pregnancy, can alter the disposition and accumulation of mercury. To test this hypothesis, pregnant and non-pregnant female Wistar rats were exposed orally to CHHg. The amount of mercury in blood and total renal mass was significantly lower in pregnant rats than in non-pregnant rats. This finding may be due to expansion of plasma volume in pregnant rats and dilution of mercury, leading to lower levels of mercury in maternal blood and kidneys.

摘要

甲基汞（CHHg）是一种常见的环境毒物，对许多器官系统都有严重的有害影响。我们假设，像怀孕这样的重大生理变化可以改变汞的分布和积累。为了验证这一假设，我们用甲基汞对怀孕和未怀孕的雌性 Wistar 大鼠进行了口服暴露。与未怀孕的大鼠相比，怀孕的大鼠血液和总肾质量中的汞含量明显降低。这一发现可能是由于怀孕大鼠的血浆容量扩大和汞的稀释，导致母血和肾脏中的汞含量降低。

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