溃疡性结肠炎和结肠腺癌之间常见和不同的遗传途径。
Common and differential genetically pathways between ulcerative colitis and colon adenocarcinoma.
作者信息
Akbari Somayeh, Hosseini Mostafa, Rezaei-Tavirani Majid, Rezaei-Tavirani Mostafa, Salehi Seyed Hamid, Alemrajabi Mahdi, Vaseghi-Maghvan Padina, Jahani-Sherafat Somayeh
机构信息
Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Gastroenterol Hepatol Bed Bench. 2017 Winter;10(Suppl1):S93-S101.
AIM
In the present study, genes of Ulcerative Colitis and Colon Adenocarcinoma (COAC) were extracted by string App in Cytoscape software version 3.5.1. Then protein- protein interaction (PPI) networks analyzed.
BACKGROUND
One of the most common chronic digestive problems is ulcerative colitis (UC) especially in developing countries. Prevalence of the disease is reported about 7.6 to 245 cases per 100,000 per year. UC can lead to colon cancer that is the third malignancy related death in the world. So awareness of the future of the patient with UC and the possibility of colon cancer is a very helpful approach.
METHODS
The analysis was based on centralities values. The goal is determining common gene pathways and differential gene pathways of the two diseases.
RESULTS
Results showed there are 11 and 29 central genes related to COAC and UC respectively. At least five common key genes between the two diseases were introduced. The number of 26 terms related to the common key genes were determined and clustered in seven clusters.
CONCLUSION
ALB, AKT1, TP53, SRC and MYC are the common genes that play crucial roles in the related biological processes of UC and COAC. Besides introducing the common genes the differentiate genes related to the two diseases were proposed.
目的
在本研究中，使用Cytoscape软件3.5.1版本中的String App提取溃疡性结肠炎和结肠腺癌（COAC）的基因。然后分析蛋白质-蛋白质相互作用（PPI）网络。
背景
溃疡性结肠炎（UC）是最常见的慢性消化问题之一，尤其是在发展中国家。据报道，该病的患病率约为每年每10万人中有7.6至245例。UC可导致结肠癌，结肠癌是全球第三大致命恶性肿瘤。因此，了解UC患者的未来以及患结肠癌的可能性是一种非常有用的方法。
方法
分析基于中心性值。目的是确定两种疾病的共同基因途径和差异基因途径。
结果
结果显示，分别有11个和29个与COAC和UC相关的中心基因。引入了两种疾病之间至少五个共同的关键基因。确定了与共同关键基因相关的26个术语，并将其聚类为七个簇。
结论
ALB、AKT1、TP53、SRC和MYC是在UC和COAC相关生物学过程中起关键作用的共同基因。除了介绍共同基因外，还提出了与两种疾病相关的差异基因。
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