脑膜炎/脑炎快速症候群检测面板的一年：儿科三级保健机构的经验。
One Year in the Life of a Rapid Syndromic Panel for Meningitis/Encephalitis: a Pediatric Tertiary Care Facility's Experience.
机构信息
Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, California, USA.
Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, California, USA
出版信息
J Clin Microbiol. 2018 Apr 25;56(5). doi: 10.1128/JCM.01940-17. Print 2018 May.
Abstract
Early establishment of infectious processes allows for expedited clinical management of meningitis and encephalitis. The FilmArray meningitis/encephalitis (FA-M/E) panel provides rapid detection of potential pathogens associated with encephalitis/meningitis in both immunocompetent and compromised patients. Here, we conducted a 1-year review of the performance of the FA-M/E panel at a tertiary care children's hospital. Two hundred sixty-five samples from 251 patients were tested. We found 87.25% (219/251) were negative, 9.96% (25/251) were positive for viral analytes, and 3.19% (8/251) were positive for bacterial analytes. When possible, positive results were confirmed by alternate testing; 4/6 available bacterial positives and 17/20 available viral positives were confirmed by retrospective culture or molecular testing.
摘要
早期确立感染过程有助于加快对脑膜炎和脑炎的临床管理。FilmArray 脑膜炎/脑炎 (FA-M/E) 检测 panel 可快速检测与免疫功能健全和受损患者的脑炎/脑膜炎相关的潜在病原体。在此，我们对一家三级儿童医院的 FA-M/E panel 进行了为期 1 年的回顾性研究。对 251 名患者的 265 个样本进行了检测。我们发现 87.25%（219/251）为阴性，9.96%（25/251）为病毒分析物阳性，3.19%（8/251）为细菌分析物阳性。在可能的情况下，通过其他检测方法对阳性结果进行了确认；6 个可用的细菌阳性和 20 个可用的病毒阳性中的 4/6 和 17/20 通过回顾性培养或分子检测得到了确认。
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