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20-HETE: Hypertension and Beyond.

作者信息

Roman Richard J, Fan Fan

机构信息

From the Department of Pharmacology, University of Mississippi Medical Center, Jackson.

出版信息

Hypertension. 2018 Jul;72(1):12-18. doi: 10.1161/HYPERTENSIONAHA.118.10269. Epub 2018 May 14.

Abstract
摘要

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20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1.
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The Blood Pressure-Lowering Effect of 20-HETE Blockade in Mice Is Associated with Natriuresis.
J Pharmacol Exp Ther. 2017 Dec;363(3):412-418. doi: 10.1124/jpet.117.243618. Epub 2017 Sep 14.
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Effect of Cytochrome P450 Metabolites of Arachidonic Acid in Nephrology.
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GPR75 Identified as the First 20-HETE Receptor: A Chemokine Receptor Adopted by a New Family.
Circ Res. 2017 May 26;120(11):1696-1698. doi: 10.1161/CIRCRESAHA.117.311022.
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20-HETE Signals Through G-Protein-Coupled Receptor GPR75 (G) to Affect Vascular Function and Trigger Hypertension.
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20-HETE attenuates the response of glucose-stimulated insulin secretion through the AKT/GSK-3β/Glut2 pathway.
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