纳米凝胶作为 CNS 递药的潜在药物纳米载体。
Nanogels as potential drug nanocarriers for CNS drug delivery.
机构信息
Centre for Personalized Nanomedicine, Institute of Neuro-Immune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.
Centre for Personalized Nanomedicine, Institute of Neuro-Immune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.
出版信息
Drug Discov Today. 2018 Jul;23(7):1436-1443. doi: 10.1016/j.drudis.2018.05.018. Epub 2018 May 20.
Hydrogel-based drug delivery systems (DDSs) have versatile applications such, as tissue engineering, scaffolds, drug delivery, and regenerative medicines. The drawback of higher size and poor stability in such DDSs are being addressed by developing nano-sized hydrogel particles, known as nanogels, to achieve the desired biocompatibility and encapsulation efficiency for better efficacy than conventional bulk hydrogels. In this review, we describe advances in the development of nanogels and their promotion as nanocarriers to deliver therapeutic agents to the central nervous system (CNS). We also discuss the challenges, possible solutions, and future prospects for the use of nanogel-based DDSs for CNS therapies.
水凝胶基药物输送系统（DDS）具有广泛的应用，如组织工程、支架、药物输送和再生医学。通过开发纳米级水凝胶颗粒（称为纳米凝胶）来解决此类 DDS 尺寸较大和稳定性差的缺点，以实现所需的生物相容性和封装效率，从而比传统的块状水凝胶具有更好的疗效。在这篇综述中，我们描述了纳米凝胶的发展进展及其作为纳米载体在将治疗剂递送到中枢神经系统（CNS）方面的应用。我们还讨论了基于纳米凝胶的 DDS 用于 CNS 治疗的挑战、可能的解决方案和未来前景。
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