从胎儿到老年：一生中大脑代谢变化的综述。
From fetus to older age: A review of brain metabolic changes across the lifespan.
机构信息
Jagiellonian University Medical College, Chair of Radiology, Kraków, Poland; Jagiellonian University, The Malopolska Centre of Biotechnology, Neurobiology Department, Kraków, Poland.
Jagiellonian University, Faculty of Management and Social Communication, Institute of Applied Psychology, Department of Cognitive Neuroscience, Kraków, Poland; SWPS University of Social Sciences and Humanities, Institute of Psychology, Warszawa, Poland.
出版信息
Ageing Res Rev. 2018 Sep;46:60-73. doi: 10.1016/j.arr.2018.05.005. Epub 2018 Jun 1.
INTRODUCTION
The knowledge of metabolic changes across the lifespan is poorly understood. Thus we systematically reviewed the available literature to determine the changes in brain biochemical composition from fetus to older age and tried to explain them in the context of neural, cognitive, and behavioural changes.
METHODS
The search identified 1262 articles regarding proton magnetic resonance spectroscopy (1H MRS) examinations through December 2017. The following data was extracted: age range of the subjects, number of subjects studied, brain regions studied, MRS sequence used, echo time, MR system, method of statistical analysis, metabolites analyzed, significant differences in metabolites concentrations with age as well as the way of presentation of the results.
RESULTS
82 studies that described brain metabolite changes with age were identified. Reports on metabolic changes related to healthy aging were analyzed and discussed among six basic age groups: fetuses, infants, children, adolescents, adults, and the elderly as well as between groups and during the whole lifetime.
DISCUSSION
The results presented in the reviewed papers provide evidence that normal aging is associated with a number of metabolic changes characteristic for every period of life. Therefore, it can be concluded that the age matching is essential for comparative studies of disease states using 1H MRS.
简介
人们对生命全程的代谢变化知之甚少。因此，我们系统地回顾了现有文献，以确定从胎儿到老年的大脑生化成分的变化，并尝试在神经、认知和行为变化的背景下对其进行解释。
方法
该搜索确定了截至 2017 年 12 月关于质子磁共振波谱（1H MRS）检查的 1262 篇文章。提取了以下数据：受试者的年龄范围、研究的受试者数量、研究的脑区、使用的 MRS 序列、回波时间、MR 系统、统计分析方法、分析的代谢物、代谢物浓度随年龄的显著差异以及结果的呈现方式。
结果
确定了 82 项描述与年龄相关的大脑代谢变化的研究。对与健康衰老相关的代谢变化报告进行了分析和讨论，共分为六个基本年龄组：胎儿、婴儿、儿童、青少年、成人和老年人，以及组间和整个生命周期。
讨论
综述论文中的结果提供了证据，证明正常衰老与每个生命阶段的许多代谢变化有关。因此，可以得出结论，在使用 1H MRS 对疾病状态进行比较研究时，年龄匹配至关重要。
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