支持健康的营养与运动研究中的体重维持与细胞衰老。
Weight Loss Maintenance and Cellular Aging in the Supporting Health Through Nutrition and Exercise Study.
机构信息
From the UCSF Department of Psychiatry (Mason, Schleicher, Prather, Epel), Center for Health and Community, San Francisco, California; UCSF Osher Center for Integrative Medicine (Mason, Hecht, Moran, Schleicher, Acree, Epel), San Francisco, California; Department of Health Education (Daubenmier), SF State University, Institute of Holistic Health Studies, San Francisco, California; Department of Psychology (Sbarra), The University of Arizona, Tucson; and UCSF Department of Biochemistry and Biophysics (Lin), San Francisco, California.
出版信息
Psychosom Med. 2018 Sep;80(7):609-619. doi: 10.1097/PSY.0000000000000616.
OBJECTIVE
The aim of the study was to determine, within a weight loss clinical trial for obesity, the impact of intervention arm, weight change, and weight loss maintenance on telomere length (TL).
METHODS
Adults (N = 194) with a body mass index between 30 and 45 were randomized to a 5.5-month weight loss program with (n = 100) or without (n = 94) mindfulness training and identical diet-exercise guidelines. We assessed TL at baseline and 3-, 6-, and 12-month postbaseline in immune cell populations (primarily in peripheral blood mononuclear cells [PBMCs], but also in granulocytes and T and B lymphocytes). We defined weight loss maintenance as having lost at least 5% or 10% of body weight (tested in separate models) from preintervention to postintervention, and having maintained this loss at 12 months. We predicted that greater weight loss and weight loss maintenance would be associated with TL lengthening.
RESULTS
Neither weight loss intervention significantly predicted TL change nor did amount of weight change, at any time point. Across all participants, weight loss maintenance of at least 10% was associated with longer PBMC TL (b = 239.08, 95% CI = 0.92 to 477.25, p = .049), CD8+ TL (b = 417.26, 95% CI = 58.95 to 775.57, p = .023), and longer granulocyte TL (b = 191.56, 95% CI = -4.23 to 387.35, p = .055) at 12 months after accounting for baseline TL. Weight loss maintenance of 5% or more was associated with longer PBMC TL (b = 163.32, 95% CI = 4.00 to 320.62, p = .045) at 12 months after accounting for baseline TL. These tests should be interpreted in light of corrections for multiple tests.
CONCLUSIONS
Among individuals with obesity, losing and maintaining a weight loss of 10% or more may lead to TL lengthening, which may portend improved immune and metabolic function. TL lengthening in this study is of unknown duration beyond 12 months and requires further study.
TRIAL REGISTRATION
Clinicaltrials.govidentifierNCT00960414; Open Science Framework (OSF) preregistration: https://osf.io/t3r2g/.
目的
本研究旨在确定在肥胖减肥临床试验中，干预组、体重变化和体重维持对端粒长度（TL）的影响。
方法
BMI 在 30 至 45 之间的成年人（N=194）被随机分配到为期 5.5 个月的减肥计划中，其中（n=100）或不（n=94）进行正念训练和相同的饮食-运动指南。我们在免疫细胞群（主要是外周血单核细胞[PBMC]，但也在粒细胞和 T 和 B 淋巴细胞中）中在基线和 3、6 和 12 个月时评估 TL。我们将体重维持定义为从干预前到干预后至少减轻 5%或 10%的体重（在单独的模型中进行测试），并在 12 个月时保持这种减轻。我们预测，更大的体重减轻和体重维持与 TL 延长有关。
结果
无论减肥干预措施如何，在任何时间点，体重减轻干预均未显著预测 TL 变化，也未预测体重减轻量。在所有参与者中，维持至少 10%的体重减轻与 PBMC TL 延长相关（b=239.08，95%CI=0.92 至 477.25，p=0.049），CD8+TL（b=417.26，95%CI=58.95 至 775.57，p=0.023）和更长的粒细胞 TL（b=191.56，95%CI=4.23 至 387.35，p=0.055），在考虑基线 TL 后 12 个月。维持 5%或更多的体重减轻与 PBMC TL 延长相关（b=163.32，95%CI=4.00 至 320.62，p=0.045），在考虑基线 TL 后 12 个月。这些测试应根据多次测试的校正进行解释。
结论
在肥胖个体中，减轻并维持 10%或更多的体重减轻可能会导致 TL 延长，这可能预示着免疫和代谢功能的改善。本研究中 TL 延长的持续时间未知，超过 12 个月，需要进一步研究。
试验注册
Clinicaltrials.gov 标识符 NCT00960414；开放科学框架（OSF）预注册：https://osf.io/t3r2g/。
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