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减重手术可减少病态肥胖患者的医疗资源利用和全因住院死亡率:一项倾向匹配分析。

Weight Loss Surgery Reduces Healthcare Resource Utilization and All-Cause Inpatient Mortality in Morbid Obesity: a Propensity-Matched Analysis.

机构信息

Division of Gastroenterology, Hepatology and Nutrition, The Ohio State University Wexner Medical Center, 395 W. 12th Avenue, 2nd floor, Columbus, OH, USA.

Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

出版信息

Obes Surg. 2018 Oct;28(10):3213-3220. doi: 10.1007/s11695-018-3345-2.

Abstract

AIMS

There is a lack of population studies evaluating the impact of bariatric surgery (BRS) on all-cause inpatient mortality. We sought to determine the impact of prior BRS on all-cause mortality and healthcare utilization in hospitalized patients.

METHODS

We analyzed the National Inpatient Sample database from 2007 to 2013. Participants were adult (≥ 18 years) inpatients admitted with a diagnosis of morbid obesity or a history of BRS. Propensity score-matched analyses were performed to compare mortality and healthcare resource utilization (hospital length of stay and cost).

RESULTS

There were 9,044,103 patient admissions with morbid obesity and 1,066,779 with prior BRS. A propensity score-matched cohort analysis demonstrated that prior BRS was associated with decreased mortality (OR = 0.58; 95% CI [0.54, 0.63]), shorter length of stay (0.59 days; P < 0.001), and lower hospital costs ($2152; P < 0.001) compared to morbid obesity. A subgroup of propensity score-matched analysis among patients with high-risk of mortality (leading ten causes of mortality in morbid obesity) revealed a consistently significant reduction in odds of mortality for patients with prior BRS (OR = 0.82; 95% CI [0.72, 0.92]).

CONCLUSION AND RELEVANCE

Hospitalized patients with a history of BRS have lower all-cause mortality and healthcare resource utilization compared to those who are morbidly obese. These observations support the continued application of BRS as an effective and resource-conscious treatment for morbid obesity.

摘要

目的

目前缺乏评估减重手术(BRS)对全因住院患者死亡率影响的人群研究。本研究旨在评估既往 BRS 对住院患者全因死亡率和医疗保健利用度的影响。

方法

我们分析了 2007 年至 2013 年的国家住院患者样本数据库。研究对象为成年(≥18 岁)住院患者,患者诊断为病态肥胖或有 BRS 史。采用倾向评分匹配分析比较死亡率和医疗资源利用度(住院时间和费用)。

结果

共纳入 9044103 例病态肥胖患者和 1066779 例既往 BRS 患者。倾向评分匹配队列分析显示,既往 BRS 与死亡率降低相关(OR=0.58;95%CI[0.54,0.63]),住院时间缩短(0.59 天;P<0.001),住院费用降低(2152 美元;P<0.001)。在病态肥胖患者中死亡率较高(导致病态肥胖的前 10 种死因)的亚组倾向评分匹配分析显示,既往 BRS 患者的死亡率降低具有显著意义(OR=0.82;95%CI[0.72,0.92])。

结论与相关性

与病态肥胖患者相比,既往接受过 BRS 治疗的住院患者全因死亡率和医疗资源利用度更低。这些观察结果支持将 BRS 继续作为治疗病态肥胖的有效且具有成本意识的方法。

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