葡萄糖调节蛋白 78（GRP78）与甾体激素在生殖系统中的相互作用。
The Interplay between Glucose-Regulated Protein 78 (GRP78) and Steroids in the Reproductive System.
机构信息
INSERM U1139, Faculty of Pharmacy, Paris Descartes University, 75006 Paris, France.
Department of Automated Biological Diagnostic and Hormonology, Cochin Hospital, University Hospital Group of Paris-Centre (GHUPC, AP-HP), 75014 Paris, France.
出版信息
Int J Mol Sci. 2018 Jun 22;19(7):1842. doi: 10.3390/ijms19071842.
The glucose-regulated protein 78 (GRP78) is a molecular chaperone that is responsible for protein folding, which belongs to the heat shock protein 70 kDa (HSPA/HSP70). Because of the conjunction of GRP78 transcription with endoplasmic reticulum stress, the chaperone plays an important role in the unfolded protein response (UPR), which is induced after the accumulation of misfolded proteins. In the last years, a significant body of research concentrated on interplay between GRP78 and sexual steroid hormones. Throughout this review, we describe the mechanisms by which GRP78 regulates steroidogenesis at multiple levels and how steroids modulate GRP78 expression in different mammalian reproductive organs. Finally, we discuss the cooperation between GRP78 and steroids for cell survival and proliferation in the context of reproduction and tumorigenesis. This new paradigm offers significant opportunities for future exploration.
葡萄糖调节蛋白 78（GRP78）是一种分子伴侣，负责蛋白质折叠，属于热休克蛋白 70kDa（HSPA/HSP70）家族。由于 GRP78 转录与内质网应激的结合，伴侣在未折叠蛋白反应（UPR）中发挥重要作用，该反应是在错误折叠蛋白积累后诱导的。在过去的几年中，大量的研究集中在 GRP78 与性甾体激素之间的相互作用上。在这篇综述中，我们描述了 GRP78 如何在多个水平上调节类固醇生成，以及类固醇如何调节不同哺乳动物生殖器官中 GRP78 的表达。最后，我们讨论了在生殖和肿瘤发生的情况下，GRP78 与类固醇在细胞存活和增殖方面的合作。这个新的范例为未来的探索提供了重要的机会。
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