哺乳动物中的抗病毒 RNA 干扰。
Antiviral RNA interference in mammals.
机构信息
Department of Microbiology and Plant Pathology, University of California, Riverside, USA.
Department of Microbiology and Plant Pathology, University of California, Riverside, USA.
出版信息
Curr Opin Immunol. 2018 Oct;54:109-114. doi: 10.1016/j.coi.2018.06.010. Epub 2018 Jul 17.
Infection of plants and insects with RNA and DNA viruses triggers Dicer-dependent production of virus-derived small interfering RNAs (vsiRNAs), which subsequently guide specific virus clearance by RNA interference (RNAi). Consistent with a major antiviral function of RNAi, productive virus infection in these eukaryotic hosts depends on the expression of virus-encoded suppressors of RNAi (VSRs). The eukaryotic RNAi pathway is highly conserved, particularly between insects and mammals. This review will discuss key recent findings that indicate a natural antiviral function of the RNAi pathway in mammalian cells. We will summarize the properties of the characterized mammalian vsiRNAs and VSRs and highlight important questions remaining to be addressed on the function and mechanism of mammalian antiviral RNAi.
植物和昆虫感染 RNA 和 DNA 病毒会触发 Dicer 依赖性产生病毒衍生的小干扰 RNA (vsiRNA)，随后通过 RNA 干扰 (RNAi) 指导特定的病毒清除。与 RNAi 的主要抗病毒功能一致，这些真核宿主中的有效病毒感染依赖于病毒编码的 RNAi 抑制剂 (VSR) 的表达。真核 RNAi 途径高度保守，特别是在昆虫和哺乳动物之间。这篇综述将讨论最近的重要发现，这些发现表明 RNAi 途径在哺乳动物细胞中具有天然的抗病毒功能。我们将总结已鉴定的哺乳动物 vsiRNA 和 VSR 的特性，并强调在哺乳动物抗病毒 RNAi 的功能和机制方面仍需解决的重要问题。
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