College of Pharmaceutical Sciences, Govt. Medical College, Kozhikode 673008, Kerala, India.
Department of Pharmaceutics, College of Pharmacy and Dentistry, Buraidah Colleges (BPC), Qassim, Saudi Arabia.
J Control Release. 2018 Oct 10;287:142-155. doi: 10.1016/j.jconrel.2018.08.033. Epub 2018 Aug 28.
Natural nanocarriers found in biological frameworks have motivated the scientists to fabricate new structures that help to build characteristic systems mimicking the natural processes. Furthermore, these bioinspired and biomimetic systems improve biocompatibility during drug and gene delivery applications. The success of such a drug delivery system depends on parameters like shape, surface, texture, movement, and preparation methods. To date, various bioinspired and biomimetic drug delivery systems are available. Bacteria-inspired, virus-inspired, fungus-inspired and mammalian cell-inspired systems are presently in the spotlight. Bioinspired or biomimetic macromolecular and nanoparticle-based drug and gene delivery systems are well studied. The bioinspired and biomimetic systems find great application in biomedicine. Drug delivery, gene delivery, theranostic, and biosensing applications are major among the biomedical applications of these versatile systems. These systems have great influence on the biological systems owing to their high biocompatibility, less toxicity, and significant interaction. Bioinspired and biomimetic systems have a bright future ahead with a lot of potentials to resolve any obstacles encountered in drug and gene delivery.
天然纳米载体存在于生物框架中,这激发了科学家们制造新的结构,帮助构建模仿自然过程的特征系统。此外,这些受生物启发和仿生的系统在药物和基因传递应用中提高了生物相容性。这种药物传递系统的成功取决于形状、表面、质地、运动和制备方法等参数。迄今为止,已经有各种受生物启发和仿生的药物传递系统。细菌启发、病毒启发、真菌启发和哺乳动物细胞启发的系统是目前的焦点。受生物启发或仿生的基于大分子和纳米粒子的药物和基因传递系统已经得到了很好的研究。受生物启发或仿生的系统在生物医学中有广泛的应用。药物传递、基因传递、治疗诊断和生物传感应用是这些多功能系统在生物医学中的主要应用。由于其高度的生物相容性、较低的毒性和显著的相互作用,这些系统对生物系统有很大的影响。受生物启发和仿生的系统具有光明的未来,具有很大的潜力来解决药物和基因传递中遇到的任何障碍。