成纤维细胞生长因子 23 超越磷酸盐激素。
FGF23 beyond Phosphotropic Hormone.
机构信息
Diabetes Therapeutics and Research Center, Institute of Advanced Medical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima, Tokushima 7708503, Japan; Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima, Tokushima 7708503, Japan.
Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima, Tokushima 7708503, Japan.
出版信息
Trends Endocrinol Metab. 2018 Nov;29(11):755-767. doi: 10.1016/j.tem.2018.08.006. Epub 2018 Sep 11.
Fibroblast growth factor (FGF) 23 is a bone-derived phosphotropic hormone that regulates phosphate and vitamin D metabolism. FGF23 mainly affects kidney function via the FGF receptor (FGFR)/α-Klotho complex. The physiological roles of FGF23 and α-Klotho in the regulation of mineral homeostasis have been well established. In addition, recent studies have reported that FGF23 has various effects on many other tissues, sometimes in an α-Klotho-independent manner, especially under pathological conditions. However, how FGF23 works in these tissues without α-Klotho is not entirely clear. Here we review the recent reports concerning the actions of FGF23 on various tissues and discuss the remaining questions about FGF23.
成纤维细胞生长因子 23（FGF23）是一种骨源磷酸酯激素，调节磷酸盐和维生素 D 代谢。FGF23 主要通过成纤维细胞生长因子受体（FGFR）/α-klotho 复合物影响肾脏功能。FGF23 和 α-klotho 在调节矿物质稳态中的生理作用已得到充分证实。此外，最近的研究报告称，FGF23 对许多其他组织具有多种作用，有时以 α-klotho 非依赖性的方式，特别是在病理条件下。然而，在没有 α-klotho 的情况下，FGF23 在这些组织中是如何发挥作用的尚不完全清楚。在这里，我们综述了最近关于 FGF23 对各种组织作用的报告，并讨论了关于 FGF23 的其他问题。
Zotero 插件