环状RNA作为心血管系统潜在的诊疗手段
Circular RNAs as Potential Theranostics in the Cardiovascular System.
作者信息
Bei Yihua, Yang Tingting, Wang Lijun, Holvoet Paul, Das Saumya, Sluijter Joost P G, Monteiro Marta Chagas, Liu Yang, Zhou Qiulian, Xiao Junjie
机构信息
Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, Shanghai 200444, China.
Department of Cardiovascular Sciences, Experimental Cardiology, KU Leuven, 3000 Leuven, Belgium.
出版信息
Mol Ther Nucleic Acids. 2018 Dec 7;13:407-418. doi: 10.1016/j.omtn.2018.09.022. Epub 2018 Oct 2.
Cardiovascular diseases (CVDs) represent the largest contributor to mortality worldwide. Identification of novel therapeutic targets and biomarkers for CVDs is urgently needed. Circular RNAs (circRNAs) are endogenous, abundant, and stable non-coding RNAs formed by back-splicing events. Their role as regulators of gene expression has been increasingly reported. Notably, circRNAs mediate essential physiological and pathological processes in the cardiovascular system. Our first aim, therefore, is to summarize recent advances in the role of circRNAs in cardiac development as well as in pathogenesis of various CVDs. Because circRNAs are stable in circulation and their dynamic changes may reflect different disease stages, they are considered ideal biomarkers. Therefore, our second aim is to review studies that have identified circulating circRNAs as biomarkers for CVDs. Finally, we discuss the shortage of functional studies and the limitations of available clinical studies and provide future perspectives.
心血管疾病（CVDs）是全球范围内导致死亡的最大因素。迫切需要确定心血管疾病的新型治疗靶点和生物标志物。环状RNA（circRNAs）是由反向剪接事件形成的内源性、丰富且稳定的非编码RNA。它们作为基因表达调节因子的作用越来越多地被报道。值得注意的是，circRNAs介导心血管系统中的重要生理和病理过程。因此，我们的首要目标是总结circRNAs在心脏发育以及各种心血管疾病发病机制中的作用的最新进展。由于circRNAs在循环中稳定，其动态变化可能反映不同的疾病阶段，因此它们被认为是理想的生物标志物。因此，我们的第二个目标是综述将循环circRNAs鉴定为心血管疾病生物标志物的研究。最后，我们讨论功能研究的不足和现有临床研究的局限性，并提供未来展望。
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