重新审视瓦堡效应：有些肿瘤会屏气。
Revisiting the Warburg Effect: Some Tumors Hold Their Breath.
机构信息
Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA.
Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA.
出版信息
Cell Metab. 2018 Nov 6;28(5):669-670. doi: 10.1016/j.cmet.2018.10.011.
Abstract
Studies have shown that tumors commonly exhibit normal or enhanced respiration in addition to glycolytic metabolism. In this issue, Courtney et al. (2018) report a reduction in mitochondrial function in kidney cancer patients and thus a classic "Warburg Effect" that further illustrates the heterogeneity of human cancer metabolism.
摘要
研究表明，肿瘤通常除了糖酵解代谢之外还表现出正常或增强的呼吸作用。在本期中，Courtney 等人（2018）报告了肾癌患者中线粒体功能的降低，从而进一步说明了人类癌症代谢的异质性的经典“Warburg 效应”。
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