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GlyConnect:糖蛋白质组学的可视化、交互和分析

GlyConnect: Glycoproteomics Goes Visual, Interactive, and Analytical.

机构信息

Proteome Informatics Group , SIB Swiss Institute of Bioinformatics , Rue Michel-Servet 1 , CH-1211 Geneva , Switzerland.

Computer Science Department , University of Geneva , CH-1227 Geneva , Switzerland.

出版信息

J Proteome Res. 2019 Feb 1;18(2):664-677. doi: 10.1021/acs.jproteome.8b00766. Epub 2019 Jan 15.

Abstract

Knowledge of glycoproteins, their site-specific glycosylation patterns, and the glycan structures that they present to their recognition partners in health and disease is gradually being built on using a range of experimental approaches. The data from these analyses are increasingly being standardized and presented in various sources, from supplemental tables in publications to localized servers in investigator laboratories. Bioinformatics tools are now needed to collect these data and enable the user to search, display, and connect glycomics and glycoproteomics to other sources of related proteomics, genomics, and interactomics information. We here introduce GlyConnect ( https://glyconnect.expasy.org/ ), the central platform of the Glycomics@ExPASy portal for glycoinformatics. GlyConnect has been developed to gather, monitor, integrate, and visualize data in a user-friendly way to facilitate the interpretation of collected glycoscience data. GlyConnect is designed to accommodate and integrate multiple data types as they are increasingly produced.

摘要

糖蛋白的知识、其特定的糖基化模式以及它们在健康和疾病中呈现给识别伙伴的聚糖结构,正逐渐通过一系列实验方法得以建立。这些分析的数据越来越多地被标准化,并在各种来源中呈现,从出版物的补充表到研究人员实验室的本地服务器。现在需要生物信息学工具来收集这些数据,并使用户能够搜索、显示和连接糖组学和糖蛋白质组学与其他相关蛋白质组学、基因组学和相互作用组学信息的来源。我们在这里介绍 GlyConnect(https://glyconnect.expasy.org/),它是 Glycomics@ExPASy 门户的糖基化信息学中心平台。GlyConnect 的开发目的是为了以用户友好的方式收集、监控、集成和可视化数据,以促进对收集的糖科学数据的解释。GlyConnect 旨在适应和整合越来越多产生的多种数据类型。

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