早、晚期儿童端粒长度可预测 14 岁时亚临床动脉粥样硬化——CardioCAPS 研究。
Early and late childhood telomere length predict subclinical atherosclerosis at age 14 yrs. - The CardioCAPS study.
机构信息
Sydney Medical School, University of Sydney, Australia; Department of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia; Heart Research Institute, Sydney, Australia.
Boden Institute of Obesity, Nutrition, Exercise and Eating Disorders, University of Sydney, Australia.
出版信息
Int J Cardiol. 2019 Mar 1;278:250-253. doi: 10.1016/j.ijcard.2018.12.065. Epub 2018 Dec 22.
INTRODUCTION
Carotid Intima Media Thickness (CIMT) is a marker of subclinical atherosclerosis, associated with cardiovascular risk in adults. Telomere length (TL) is a marker of cellular ageing. We sought to determine whether telomere length in early childhood and/or at 14-years is associated with CIMT in adolescence, in a community-based cohort study.
METHODS
118 children had TL measured at mean age 3.6-years and 165 children had TL and CIMT, measured at 14-years, from the community-based Childhood Asthma Prevention Study.
RESULTS
TL in early childhood was significantly inversely associated with CIMT at 14 years, p = 0.04. TL in teenage life was also significantly inversely associated with CIMT at 14 years, p = 0.03. This latter association was no longer significant, however, after adjusting for early life TL.
CONCLUSION
TL measured in early childhood and adolescence is significantly associated with CIMT at 14-years, suggesting that telomere length is a biological marker or even early determinant of late cardiovascular risk.
简介
颈动脉内膜中层厚度（CIMT）是亚临床动脉粥样硬化的标志物，与成年人的心血管风险相关。端粒长度（TL）是细胞衰老的标志物。我们旨在确定在基于社区的队列研究中，儿童早期和/或 14 岁时的端粒长度是否与青春期的 CIMT 相关。
方法
从基于社区的儿童哮喘预防研究中，有 118 名儿童在平均年龄为 3.6 岁时测量了 TL，有 165 名儿童在 14 岁时测量了 TL 和 CIMT。
结果
儿童早期的 TL 与 14 岁时的 CIMT 呈显著负相关，p=0.04。青少年时期的 TL 也与 14 岁时的 CIMT 呈显著负相关，p=0.03。然而，在调整了早期 TL 后，这种关联不再显著。
结论
在儿童早期和青少年时期测量的 TL 与 14 岁时的 CIMT 显著相关，这表明端粒长度是晚期心血管风险的生物学标志物甚至早期决定因素。
Zotero 插件