EMT 转录因子的非冗余功能。

Non-redundant functions of EMT transcription factors.

机构信息

Department of Experimental Medicine 1, Nikolaus-Fiebiger-Center for Molecular Medicine, FAU University Erlangen-Nürnberg, Erlangen, Germany.

出版信息

Nat Cell Biol. 2019 Jan;21(1):102-112. doi: 10.1038/s41556-018-0196-y. Epub 2019 Jan 2.

DOI:10.1038/s41556-018-0196-y

PMID:30602760

Abstract

Epithelial-mesenchymal transition (EMT) is a crucial embryonic programme that is executed by various EMT transcription factors (EMT-TFs) and is aberrantly activated in cancer and other diseases. However, the causal role of EMT and EMT-TFs in different disease processes, especially cancer and metastasis, continues to be debated. In this Review, we identify and describe specific, non-redundant functions of the different EMT-TFs and discuss the reasons that may underlie disputes about EMT in cancer.

摘要

上皮-间充质转化（EMT）是一个关键的胚胎程序，由各种 EMT 转录因子（EMT-TFs）执行，并在癌症和其他疾病中异常激活。然而，EMT 和 EMT-TFs 在不同疾病过程中的因果作用，特别是在癌症和转移中，仍存在争议。在这篇综述中，我们确定并描述了不同 EMT-TFs 的具体的、非冗余的功能，并讨论了导致癌症中 EMT 争议的原因。

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Co-optation of Tandem DNA Repeats for the Maintenance of Mesenchymal Identity.

Cell. 2018 May 17;173(5):1150-1164.e14. doi: 10.1016/j.cell.2018.03.081. Epub 2018 Apr 26.

Identification of the tumour transition states occurring during EMT.

Nature. 2018 Apr;556(7702):463-468. doi: 10.1038/s41586-018-0040-3. Epub 2018 Apr 18.

EMT in cancer.

Nat Rev Cancer. 2018 Feb;18(2):128-134. doi: 10.1038/nrc.2017.118. Epub 2018 Jan 12.

Oridonin exerts anticancer effect on osteosarcoma by activating PPAR-γ and inhibiting Nrf2 pathway.

Cell Death Dis. 2018 Jan 11;9(1):15. doi: 10.1038/s41419-017-0031-6.

Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1.

Nat Commun. 2017 Dec 20;8(1):2207. doi: 10.1038/s41467-017-02243-3.

Proapoptotic PUMA targets stem-like breast cancer cells to suppress metastasis.

J Clin Invest. 2018 Jan 2;128(1):531-544. doi: 10.1172/JCI93707. Epub 2017 Dec 11.

Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma.

Nat Commun. 2017 Nov 24;8(1):1758. doi: 10.1038/s41467-017-01500-9.

Role of epithelial to mesenchymal transition associated genes in mammary gland regeneration and breast tumorigenesis.

Nat Commun. 2017 Nov 21;8(1):1669. doi: 10.1038/s41467-017-01666-2.

USP51 promotes deubiquitination and stabilization of ZEB1.

Am J Cancer Res. 2017 Oct 1;7(10):2020-2031. eCollection 2017.

Breast tumor cell-specific knockout of inhibits cancer cell plasticity, dissemination, and lung metastasis in mice.

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EMT 转录因子的非冗余功能。

Non-redundant functions of EMT transcription factors.

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