对一家三级护理医院中患有妊娠期糖尿病的孟加拉妇女血清锌、铜和镁水平的评估。
Estimation of Serum Zinc, Copper and Magnesium Levels in Bangladeshi women with Gestational Diabetes Mellitus Attending in a Tertiary Care Hospital.
作者信息
Mishu F A, Boral N, Ferdous N, Nahar S, Sultana G S, Yesmin M S, Khan N Z
机构信息
Dr Farzana Akonjee Mishu, Assistant Professor of Biochemistry, Department of Physiology and Molecular Biology, Bangladesh Institute of Research & Rehabilitation in Diabetes, Endocrine & Metabolic Disorders (BIRDEM), Dhaka, Bangladesh; E-mail:
出版信息
Mymensingh Med J. 2019 Jan;28(1):157-162.
Zinc (Zn), Copper (Cu) and Magnesium (Mg) are essential trace elements for normal embryogenesis and fetal growth. Alteration of Zn, Cu and Mg concentrations in blood has been observed in normal pregnancy as well as in gestational diabetes mellitus (GDM). Aim of this study was to evaluate the serum Zn, Cu and Mg levels in Bangladeshi women with GDM in their second and third trimester of pregnancy. This descriptive cross sectional study was conducted at Mymensingh Medical College Hospital (MMCH), Mymensingh, Bangladesh from July 2013 to June 2014. Pregnant women, in their second and third trimester, attending the outpatient department of Obstetrics and Gynecology and the Department of Endocrinology of MMCH were enrolled by purposive sampling technique. GDM was diagnosed on the basis of oral glucose tolerance test (OGTT) as defined in WHO criteria 2013. Out of 172 participants, 86 had GDM (Case) and 86 were normoglycemic (control). The mean age of GDM and control groups was 28.6±3.2 years and 27.3±3.1 years respectively. The BMI was 26.4±1.5kg/m² and 26.3±1.3kg/m². In this study we found serum Zn levels in GDM cases were significantly (p<0.001) low in both trimesters (43.93±5.48μg/dl and 46.86±3.12μg/dl) compared to those without GDM (67.30±7.81μg/dl and 67.58±9.12μg/dl). On the contrary, serum Cu levels in GDM cases were significantly (p<0.001) higher in both trimesters (224±3.8μg/dl and 243.91±6.9μg/dl) compared to those without GDM (220.1±7.6μg/dl and 234.9±4.6μg/dl). There was significant (p<0.001) increase of serum Cu levels in 3rd trimester compared to 2nd trimester in both GDM and non GDM cases. Serum Mg level was significantly low (p<0.001) in 2nd and 3rd trimesters in GDM cases (1.39±0.26mg/dl and 0.93±0.15mg/dl) compared to control group (1.67±0.30mg/dl and 1.67±0.31mg/dl). There was distinct alteration of serum Zn, Cu and Mg levels in GDM compared to normal pregnancy.
锌（Zn）、铜（Cu）和镁（Mg）是正常胚胎发育和胎儿生长所必需的微量元素。在正常妊娠以及妊娠期糖尿病（GDM）中，均观察到血液中锌、铜和镁浓度的变化。本研究的目的是评估孟加拉国患有妊娠期糖尿病的妇女在妊娠中期和晚期的血清锌、铜和镁水平。这项描述性横断面研究于2013年7月至2014年6月在孟加拉国迈门辛市的迈门辛医学院医院（MMCH）进行。通过目的抽样技术，招募了在MMCH妇产科门诊和内分泌科就诊的妊娠中期和晚期孕妇。根据世界卫生组织2013年标准定义的口服葡萄糖耐量试验（OGTT）诊断妊娠期糖尿病。在172名参与者中，86名患有妊娠期糖尿病（病例组），86名血糖正常（对照组）。妊娠期糖尿病组和对照组的平均年龄分别为28.6±3.2岁和27.3±3.1岁。体重指数分别为26.4±1.5kg/m²和26.3±1.3kg/m²。在本研究中，我们发现妊娠期糖尿病病例在两个孕期的血清锌水平均显著低于无妊娠期糖尿病者（分别为43.93±5.48μg/dl和46.86±3.12μg/dl，而无妊娠期糖尿病者为67.30±7.81μg/dl和67.58±9.12μg/dl）（p<0.001）。相反，妊娠期糖尿病病例在两个孕期的血清铜水平均显著高于无妊娠期糖尿病者（分别为224±3.8μg/dl和243.91±6.9μg/dl，而无妊娠期糖尿病者为220.1±7.6μg/dl和234.9±4.6μg/dl）（p<0.001）。在妊娠期糖尿病和非妊娠期糖尿病病例中，与妊娠中期相比，妊娠晚期血清铜水平均显著升高（p<0.001）。与对照组（分别为1.67±0.30mg/dl和1.67±0.31mg/dl）相比，妊娠期糖尿病病例在妊娠中期和晚期的血清镁水平显著降低（p<0.001）（分别为1.39±0.26mg/dl和0.93±0.15mg/dl）。与正常妊娠相比，妊娠期糖尿病患者的血清锌、铜和镁水平有明显变化。
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