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抗肿瘤药物靶点分析:现状与展望。

Anti-tumor Drug Targets Analysis: Current Insight and Future Prospect.

机构信息

Department of Pharmacy, Yijishan Affiliated Hospital of Wannan Medical College, Wuhu, Anhui Province, China.

The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, School of Pharmacy, Institute for Liver Disease of Anhui Medical University, Hefei, Anhui Province, China.

出版信息

Curr Drug Targets. 2019;20(11):1180-1202. doi: 10.2174/1389450120666190402145325.

Abstract

The incidence and mortality of malignant tumors are on the rise, which has become the second leading cause of death in the world. At present, anti-tumor drugs are one of the most common methods for treating cancer. In recent years, with the in-depth study of tumor biology and related disciplines, it has been gradually discovered that the essence of cell carcinogenesis is the infinite proliferation of cells caused by the disorder of cell signal transduction pathways, followed by a major shift in the concept of anti-tumor drugs research and development. The focus of research and development is shifting from traditional cytotoxic drugs to a new generation of anti-tumor drugs targeted at abnormal signaling system targets in tumor cells. In this review, we summarize the targets of anti-tumor drugs and analyse the molecular mechanisms of their effects, which lay a foundation for subsequent treatment, research and development.

摘要

恶性肿瘤的发病率和死亡率呈上升趋势,已成为全球第二大致死原因。目前,抗肿瘤药物是治疗癌症最常用的方法之一。近年来,随着对肿瘤生物学及相关学科的深入研究,逐渐发现细胞癌变的本质是细胞信号转导通路紊乱导致的细胞无限增殖,随后抗肿瘤药物研发的概念发生重大转变。研究和开发的重点正从传统的细胞毒性药物转向针对肿瘤细胞异常信号系统靶点的新一代抗肿瘤药物。本文综述了抗肿瘤药物的靶点,并分析了其作用的分子机制,为后续的治疗、研究和开发奠定了基础。

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