癌基因c-MYC调控SW620细胞系中PBAF染色质重塑复合物的PHF10亚基的表达。
Oncogene c-MYC Controls the Expression of PHF10 Subunit of PBAF Chromatin Remodeling Complex in SW620 Cell Line.
作者信息
Tatarskiy Eu V, Georgiev G P, Soshnikova N V
机构信息
Institute of Gene Biology, Russian Academy of Sciences, 119334, Moscow, Russia.
出版信息
Dokl Biochem Biophys. 2019 May;484(1):66-68. doi: 10.1134/S1607672919010204. Epub 2019 Apr 22.
The PBAF(SWI/SNF) multiprotein complex, which changes the chromatin structure, is widely involved in the regulation of eukaryotic gene expression. A specific component of this complex is the PHF10 protein, which is involved in recruiting this complex to chromatin. We showed that the PHF10 expression in cells of different lines is activated by the c-MYC oncogene. Since PHF10 stimulates cell proliferation, its c-MYC-dependent activation in cancer cells should lead to an increase in their proliferation rate.
可改变染色质结构的PBAF（SWI/SNF）多蛋白复合物广泛参与真核基因表达的调控。该复合物的一个特定组分是PHF10蛋白，它参与将此复合物招募至染色质。我们发现，不同细胞系中的PHF10表达由c-MYC癌基因激活。由于PHF10可刺激细胞增殖，其在癌细胞中依赖c-MYC的激活应会导致癌细胞增殖速率增加。
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