Phf10蛋白（一种PBAF染色质重塑复合物亚基）的水平与人类癌细胞系中的Mts1/S100A4表达相关。
The level of the Phf10 protein, a PBAF chromatin-remodeling complex subunit, correlates with the Mts1/S100A4 expression in human cancer cell lines.
作者信息
Soshnikova N V, Simonov Yu P, Brechalov A V, Portseva T N, Pankratova E V, Georgieva S G
机构信息
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, ul. Vavilova 32, Moscow, 119991, Russia.
出版信息
Dokl Biochem Biophys. 2016 Mar;467(1):162-4. doi: 10.1134/S1607672916020228. Epub 2016 May 20.
Mts1 (S100A4) protein is a marker of metastatic tumor cells, which is associated with a poor diagnostic prognosis for cancer progression. Therefore, it is important to study the S100A4 gene expression. According to our preliminary data, PHF10, a PBAF remodeling complex component, can play an important role in the transcription regulation of the S100A4 gene. We studied the expression of S100A4 and the total PHF10 protein in some cell lines. We have found that, in the cell lines studied, the PHF10 expression is correlated with the S100A4 expression.
Mts1（S100A4）蛋白是转移性肿瘤细胞的标志物，与癌症进展的不良诊断预后相关。因此，研究S100A4基因表达很重要。根据我们的初步数据，PBAF重塑复合体成分PHF10可在S100A4基因的转录调控中发挥重要作用。我们研究了一些细胞系中S100A4和总PHF10蛋白的表达。我们发现，在所研究的细胞系中，PHF10表达与S100A4表达相关。
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