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用于生物医学微/纳米机器人的生物相容性推进。

Biocompatible propulsion for biomedical micro/nano robotics.

机构信息

Department of Health Technology, Technical University of Denmark, DK-2800, Kgs Lyngby, Denmark.

出版信息

Biosens Bioelectron. 2019 Aug 15;139:111334. doi: 10.1016/j.bios.2019.111334. Epub 2019 May 17.

Abstract

Micro/Nano robots have shown enormous potential for diverse biomedical applications, such as targeted delivery, in vivo biosensing, minimally invasive surgery and cell manipulation through extending their area of operation to various previously inaccessible locations. The motion of these small-scale robots can be either self-propelled or remotely controlled by some external power sources. However, in order to use them for biomedical applications, optimization of biocompatible propulsion and precise controllability are highly desirable. In this article, the recent progress about the biocompatible propulsion (e.g. self-propulsion, external stimuli based propulsion and bio-hybrid propulsion) techniques for these micro/nano robotic devices are summarized along with their applications, with a special focus on the advantages and disadvantages of different propulsion techniques. The current challenges and future perspectives of these small-scale devices are discussed in the final section.

摘要

微/纳米机器人在靶向药物输送、活体生物传感、微创手术以及细胞操作等生物医学领域具有广泛的应用潜力,它们将操作范围扩展到各种以前无法到达的位置。这些微型机器人的运动可以是自推进的,也可以通过外部电源远程控制。然而,为了将它们应用于生物医学领域,对生物相容性推进和精确可控性的优化是非常有必要的。本文综述了用于这些微/纳米机器人的生物相容性推进技术(例如自推进、基于外部刺激的推进和生物杂交推进)的最新进展及其应用,特别关注不同推进技术的优缺点。在最后一节中,讨论了这些小型设备目前所面临的挑战和未来的发展方向。

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