动物模型：确定胰腺炎和胰腺癌最佳实验模型的挑战与机遇。
Animal Models: Challenges and Opportunities to Determine Optimal Experimental Models of Pancreatitis and Pancreatic Cancer.
机构信息
Division of Gastroenterology, Hepatology, and Nutrition, Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, OH.
Basic and Translational Pancreas Research, Cedars-Sinai Medical Center.
出版信息
Pancreas. 2019 Jul;48(6):759-779. doi: 10.1097/MPA.0000000000001335.
At the 2018 PancreasFest meeting, experts participating in basic research met to discuss the plethora of available animal models for studying exocrine pancreatic disease. In particular, the discussion focused on the challenges currently facing the field and potential solutions. That meeting culminated in this review, which describes the advantages and limitations of both common and infrequently used models of exocrine pancreatic disease, namely, pancreatitis and exocrine pancreatic cancer. The objective is to provide a comprehensive description of the available models but also to provide investigators with guidance in the application of these models to investigate both environmental and genetic contributions to exocrine pancreatic disease. The content covers both nongenic and genetically engineered models across multiple species (large and small). Recommendations for choosing the appropriate model as well as how to conduct and present results are provided.
在 2018 年 PancreasFest 会议上，参与基础研究的专家齐聚一堂，讨论了目前可用于研究外分泌胰腺疾病的大量动物模型。特别是，讨论集中在该领域目前面临的挑战和潜在的解决方案上。此次会议的成果是本综述，它描述了常见和不常使用的外分泌胰腺疾病模型（即胰腺炎和外分泌胰腺癌症）的优缺点。其目的是全面描述现有的模型，同时为研究人员提供在应用这些模型来研究外分泌胰腺疾病的环境和遗传因素方面的指导。内容涵盖了多种物种（大动物和小动物）的非基因和基因工程模型。提供了选择合适模型的建议，以及如何进行和呈现结果的建议。
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