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利用 Crispr CAS9 的肺癌可翻译基因治疗:探索性综述。

Translatable gene therapy for lung cancer using Crispr CAS9-an exploratory review.

机构信息

Cellular and Molecular Therapeutics Laboratory, Center for Biomaterials, Cellular and Molecular Theranostics, Vellore Institute of Technology, Vellore, Tamil Nadu, 632014, India.

出版信息

Cancer Gene Ther. 2020 Apr;27(3-4):116-124. doi: 10.1038/s41417-019-0116-8. Epub 2019 Jun 20.

Abstract

Gene therapy using CRISPR Cas9 technique is rapidly gaining popularity among the scientific community primarily because of its versatility, cost-effectiveness, and high efficacy. While the laboratory-based experiments and findings making use of CRISPR as a gene editing tool are available in ample amounts, the question arises that how much of these findings are actually translatable into measures helping in combating particular disease conditions. In this review, we highlight the important studies and findings done till now in the perspective of lung cancer with an in-depth analysis of various clinical trials associated with the use of CRISPR Cas9 technology in the field of cancer research.

摘要

使用 CRISPR Cas9 技术的基因治疗在科学界迅速流行,主要是因为它的多功能性、成本效益和高效性。虽然有大量基于实验室的实验和利用 CRISPR 作为基因编辑工具的发现,但问题是这些发现中有多少实际上可以转化为有助于对抗特定疾病状况的措施。在这篇综述中,我们从肺癌的角度强调了迄今为止所做的重要研究和发现,并深入分析了与癌症研究中使用 CRISPR Cas9 技术相关的各种临床试验。

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