早期益生菌补充与遗传风险儿童中乳糜泻风险的关系。
Early Probiotic Supplementation and the Risk of Celiac Disease in Children at Genetic Risk.
机构信息
Health Informatics Institute, Department of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
The Diabetes and Celiac Disease Unit, Department of Clinical Sciences, Lund University, 214 28 Malmö, Sweden.
出版信息
Nutrients. 2019 Aug 2;11(8):1790. doi: 10.3390/nu11081790.
Probiotics are linked to positive regulatory effects on the immune system. The aim of the study was to examine the association between the exposure of probiotics via dietary supplements or via infant formula by the age of 1 year and the development of celiac disease autoimmunity (CDA) and celiac disease among a cohort of 6520 genetically susceptible children. Use of probiotics during the first year of life was reported by 1460 children. Time-to-event analysis was used to examine the associations. Overall exposure of probiotics during the first year of life was not associated with either CDA ( = 1212) (HR 1.15; 95%CI 0.99, 1.35; = 0.07) or celiac disease ( = 455) (HR 1.11; 95%CI 0.86, 1.43; = 0.43) when adjusting for known risk factors. Intake of probiotic dietary supplements, however, was associated with a slightly increased risk of CDA (HR 1.18; 95%CI 1.00, 1.40; = 0.043) compared to children who did not get probiotics. It was concluded that the overall exposure of probiotics during the first year of life was not associated with CDA or celiac disease in children at genetic risk.
益生菌与免疫系统的正向调节作用有关。本研究的目的是在 6520 名遗传易感儿童队列中，通过膳食补充剂或婴儿配方奶粉在 1 岁前暴露于益生菌，来检验益生菌暴露与乳糜泻自身免疫（CDA）和乳糜泻发展之间的关联。有 1460 名儿童报告在生命的第一年使用了益生菌。采用时间事件分析来检验关联。在生命的第一年总体暴露于益生菌与 CDA（ = 1212）（HR 1.15；95%CI 0.99，1.35； = 0.07）或乳糜泻（ = 455）（HR 1.11；95%CI 0.86，1.43； = 0.43）均无关联，同时调整了已知的风险因素。然而，与未摄入益生菌的儿童相比，摄入益生菌膳食补充剂与 CDA 的风险略有增加（HR 1.18；95%CI 1.00，1.40； = 0.043）。总之，在生命的第一年总体暴露于益生菌与遗传风险儿童的 CDA 或乳糜泻无关。
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