果蝇中多梳蛋白和触角足突变的剂量依赖性修饰因子
Dosage-dependent modifiers of polycomb and antennapedia mutations in Drosophila.
作者信息
Kennison J A, Tamkun J W
机构信息
Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, MD 20892.
出版信息
Proc Natl Acad Sci U S A. 1988 Nov;85(21):8136-40. doi: 10.1073/pnas.85.21.8136.
Two genes known to control the determination of segmental identity in Drosophila melanogaster are polycomb and antennapedia. To identify additional genes involved in the determination of segmental identity, we have isolated dominant modifers (both suppressors and enhancers) of polycomb and/or antennapedia mutations. Sixty-four such modifier mutations have been recovered and mapped to 18 complementation groups. All of the mutations identify genes necessary for viability of the zygote. Six of the 18 genes that were identified by mutations that interact with polycomb and/or antennapedia have been previously characterized as homoeotic genes [i.e., Sex combs reduced (Scr), Brista (Ba), trithorax (trx), Polycomb (Pc), Polycomblike (Pcl), and Sex comb on midleg (Scm)]. Mutations in several of the additional loci identified here have also been shown to have homoeotic phenotypes.
已知在黑腹果蝇中控制体节身份决定的两个基因是多梳基因和触角足基因。为了鉴定参与体节身份决定的其他基因，我们分离了多梳基因和/或触角足基因突变的显性修饰因子（包括抑制子和增强子）。已经获得了64个这样的修饰基因突变，并将其定位到18个互补群中。所有这些突变都鉴定出了合子存活所必需的基因。通过与多梳基因和/或触角足基因相互作用的突变鉴定出的18个基因中的6个，先前已被表征为同源异型基因[即，性梳减少（Scr）、刚毛（Ba）、三胸节（trx）、多梳基因（Pc）、多梳基因样（Pcl）和中腿性梳（Scm）]。这里鉴定出的几个其他位点的突变也已被证明具有同源异型表型。
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