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对于病毒储存库研究,时机很重要。

For Viral Reservoir Studies, Timing Matters.

机构信息

Centre for Virus Research, The Westmead Institute of Medical Research, The University of Sydney, Sydney, New South Wales, 2145, Australia; Sydney Medical School, Westmead Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, 2006, Australia.

Centre for Virus Research, The Westmead Institute of Medical Research, The University of Sydney, Sydney, New South Wales, 2145, Australia; Sydney Medical School, Westmead Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, 2006, Australia.

出版信息

Trends Microbiol. 2019 Oct;27(10):809-810. doi: 10.1016/j.tim.2019.08.003. Epub 2019 Aug 17.

Abstract

New strategies to eliminate persistent HIV-1 during therapy will benefit from animal models, such as non-human primates infected with simian immunodeficiency viruses (SIV) or chimeras (SHIV). Understanding the genetic composition of SIV and SHIV reservoirs during therapy is therefore crucial for the future application of this model.

摘要

新的策略来消除治疗期间持续存在的 HIV-1 将受益于动物模型,如感染猴免疫缺陷病毒 (SIV) 或嵌合体 (SHIV) 的非人类灵长类动物。因此,了解治疗期间 SIV 和 SHIV 储库的遗传组成对于该模型的未来应用至关重要。

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