微小RNA-145：癌症迁移和侵袭的潜在生物标志物。
MiR-145: a potential biomarker of cancer migration and invasion.
作者信息
Xu Wen-Xiu, Liu Zhen, Deng Fei, Wang Dan-Dan, Li Xing-Wang, Tian Tian, Zhang Jian, Tang Jin-Hai
机构信息
Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University Nanjing 210029, P. R. China.
The First Clinical School of Nanjing Medical University Nanjing 210029, P. R. China.
出版信息
Am J Transl Res. 2019 Nov 15;11(11):6739-6753. eCollection 2019.
Abstract
MircoRNAs (miRNAs) are a diverse family of highly-conserved small non-coding RNAs, which range from approximately 18 to 25 nucleotides in size. They regulate gene expression transcriptionally or post-transcriptionally via binding to the 3'-untranslated region (3'-UTR) of target message RNAs (mRNAs). MiRNAs have emerged as molecular regulators that participate in physiological and pathological processes of diverse malignancies. Among them, miRNA-145 (miR-145) played a profound role in tumorigenesis and progression of various neoplasms. In this review, we summarized the recent findings regarding miR-145, to elucidate its functional roles in cell invasion and migration of diverse human malignancies, and considered it a potential biomarker for cancer diagnosis, screening, and prognosis.
摘要
微小RNA（miRNA）是一个多样化的高度保守的小非编码RNA家族，其大小约为18至25个核苷酸。它们通过与靶信使RNA（mRNA）的3'-非翻译区（3'-UTR）结合，在转录或转录后水平调节基因表达。miRNA已成为参与多种恶性肿瘤生理和病理过程的分子调节因子。其中，miRNA-145（miR-145）在各种肿瘤的发生和发展中发挥着重要作用。在本综述中，我们总结了关于miR-145的最新研究结果，以阐明其在多种人类恶性肿瘤细胞侵袭和迁移中的功能作用，并认为它是癌症诊断、筛查和预后的潜在生物标志物。
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本文引用的文献
1
Circulating miRNAs as non-invasive biomarkers to predict aggressive prostate cancer after radical prostatectomy.
J Transl Med. 2019 May 23;17(1):173. doi: 10.1186/s12967-019-1920-5.
2
Long noncoding RNA UCA1 promotes the proliferation, invasion, and migration of nasopharyngeal carcinoma cells via modulation of miR-145.
Onco Targets Ther. 2018 Oct 25;11:7483-7492. doi: 10.2147/OTT.S182290. eCollection 2018.
3
Retracted: microRNA-145 regulates tumor suppressor candidate 3 and mitogen-activated protein kinase pathway to inhibit the progression of colorectal cancer.
J Cell Biochem. 2019 May;120(5):8376-8384. doi: 10.1002/jcb.28122. Epub 2018 Nov 28.
4
MYPT1 is targeted by miR-145 inhibiting viability, migration and invasion in 2D and 3D HeLa cultures.
Biochem Biophys Res Commun. 2018 Dec 9;507(1-4):348-354. doi: 10.1016/j.bbrc.2018.11.039. Epub 2018 Nov 14.
5
Circ_0058063 regulates CDK6 to promote bladder cancer progression by sponging miR-145-5p.
J Cell Physiol. 2019 Apr;234(4):4812-4824. doi: 10.1002/jcp.27280. Epub 2018 Oct 26.
6
Promoter Methylation-Regulated miR-145-5p Inhibits Laryngeal Squamous Cell Carcinoma Progression by Targeting FSCN1.
Mol Ther. 2019 Feb 6;27(2):365-379. doi: 10.1016/j.ymthe.2018.09.018. Epub 2018 Sep 27.
7
The effects of lncRNA MALAT1 on proliferation, invasion and migration in colorectal cancer through regulating SOX9.
Mol Med. 2018 Oct 3;24(1):52. doi: 10.1186/s10020-018-0050-5.
8
Estrogen receptor β promotes the vasculogenic mimicry (VM) and cell invasion via altering the lncRNA-MALAT1/miR-145-5p/NEDD9 signals in lung cancer.
Oncogene. 2019 Feb;38(8):1225-1238. doi: 10.1038/s41388-018-0463-1. Epub 2018 Sep 24.
9
The circular RNA circ-ITCH suppresses ovarian carcinoma progression through targeting miR-145/RASA1 signaling.
Biochem Biophys Res Commun. 2018 Oct 20;505(1):222-228. doi: 10.1016/j.bbrc.2018.09.060. Epub 2018 Sep 19.
10
The Dysregulated Expression of KCNQ1OT1 and Its Interaction with Downstream Factors miR-145/CCNE2 in Breast Cancer Cells.
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